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Title
Essential and non-essential metals : carcinogenesis, prevention and cancer therapeutics / Anuradha Mudipalli, Judith T. Zelikoff, editors.
ISBN
9783319554488 (electronic book)
3319554484 (electronic book)
9783319554464
Published
Cham, Switzerland : Humana Press, 2017.
Language
English
Description
1 online resource (xii, 228 pages) : illustrations.
Call Number
RC268.6
Dewey Decimal Classification
616.99/4071
Summary
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed July 24, 2017).
Series
Molecular and integrative toxicology.
Calcium channels and pumps important during lactation as potential targets for breast cancer
Tumor development through the Mg2+nifying glass
Selenium: roles in cancer prevention and therapies
Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics
Arsenic Carcinogenesis
Cadmium Carcinogenesis and Mechanistic Insights
Molecular Mechanisms of Chromium-Induced Carcinogenesis
Mechanisms of Nickel Carcinogenesis
Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
