000796310 000__ 03428cam\a2200457Ii\4500
000796310 001__ 796310
000796310 005__ 20230306143534.0
000796310 006__ m\\\\\o\\d\\\\\\\\
000796310 007__ cr\cnunnnunuuu
000796310 008__ 170718s2017\\\\sz\a\\\\o\\\\\001\0\eng\d
000796310 020__ $$a9783319554488$$q(electronic book)
000796310 020__ $$a3319554484$$q(electronic book)
000796310 020__ $$z9783319554464
000796310 035__ $$aSP(OCoLC)ocn994006138
000796310 035__ $$aSP(OCoLC)994006138
000796310 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dN$T$$dYDX$$dOCLCF$$dNJR$$dUAB
000796310 049__ $$aISEA
000796310 050_4 $$aRC268.6
000796310 08204 $$a616.99/4071$$223
000796310 24500 $$aEssential and non-essential metals :$$bcarcinogenesis, prevention and cancer therapeutics /$$cAnuradha Mudipalli, Judith T. Zelikoff, editors.
000796310 264_1 $$aCham, Switzerland :$$bHumana Press,$$c2017.
000796310 300__ $$a1 online resource (xii, 228 pages) :$$billustrations.
000796310 336__ $$atext$$btxt$$2rdacontent
000796310 337__ $$acomputer$$bc$$2rdamedia
000796310 338__ $$aonline resource$$bcr$$2rdacarrier
000796310 4901_ $$aMolecular and integrative toxicology,$$x2168-4219
000796310 500__ $$aIncludes index.
000796310 5050_ $$aCalcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
000796310 506__ $$aAccess limited to authorized users.
000796310 520__ $$aThis book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
000796310 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 24, 2017).
000796310 650_0 $$aChemical carcinogenesis.
000796310 650_0 $$aMetals$$xPhysiological effect.
000796310 650_0 $$aMetals$$xTherapeutic use.
000796310 7001_ $$aMudipalli, Anuradha,$$eeditor.
000796310 7001_ $$aZelikoff, Judith T.,$$eeditor.
000796310 830_0 $$aMolecular and integrative toxicology.
000796310 852__ $$bebk
000796310 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-55448-8$$zOnline Access$$91397441.1
000796310 909CO $$ooai:library.usi.edu:796310$$pGLOBAL_SET
000796310 980__ $$aEBOOK
000796310 980__ $$aBIB
000796310 982__ $$aEbook
000796310 983__ $$aOnline
000796310 994__ $$a92$$bISE