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000796344 019__ $$a993878124$$a994315879
000796344 020__ $$a9789811031625$$q(electronic book)
000796344 020__ $$a9811031622$$q(electronic book)
000796344 020__ $$z9811031614
000796344 020__ $$z9789811031618
000796344 035__ $$aSP(OCoLC)ocn994108294
000796344 035__ $$aSP(OCoLC)994108294$$z(OCoLC)993878124$$z(OCoLC)994315879
000796344 040__ $$aYDX$$beng$$cYDX$$dN$T$$dGW5XE$$dEBLCP$$dN$T$$dNJR$$dYDX$$dUAB
000796344 049__ $$aISEA
000796344 050_4 $$aQP609.P78
000796344 08204 $$a572/.76$$223
000796344 24500 $$aProteases in human diseases /$$cSajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla, editors.
000796344 260__ $$aSingapore :$$bSpringer,$$c2017.
000796344 300__ $$a1 online resource :$$billustrations.
000796344 336__ $$atext$$btxt$$2rdacontent
000796344 337__ $$acomputer$$bc$$2rdamedia
000796344 338__ $$aonline resource$$bcr$$2rdacarrier
000796344 504__ $$aIncludes bibliographical references.
000796344 5050_ $$a1. Matrix metalloproteases in breast carcinoma, immunohistology and prognosis -- 2. Matrix metalloproteases in parasite infection -- 3. Cysteine cathepsins: In health and rheumatoid arthritis -- 4. Protective role of antiproteases in radiation induced damage -- 5. Role of proteases in the regulation of N-myristoyltransferase -- 6. Proteases in cancer: Potential therapeutic targets -- 7. MMPs in oral squamous cell carcinoma -- 8. Caspase regulatory mechanisms: Implications in pathogenesis and therapeutics -- 9. Physiological and pathological functions of mitochondrial proteases -- 10. Proteases of parasitic helminths: their metabolic role in establishment of infection in the host -- 11. Cysteine proteases of parasitic helminths -- 12. targeting proteases in urine for bladder cancer diagnosis -- 13. Intramembrane cleaving proteases (ICLiPs), particularly the gamma secretase protease and its role in neurodegeneration, cancer and innate immune signalling -- 14. Contribution of matrix metalloproteases in cardiovascular diseases -- 15. OPG/RANKL-protease axis in cardiometabolic diseases -- 16. Proteases and protease inhibitors in male reproduction -- 17. The role of MMP-2 and -9 in embryonic neural crest cells and their derivatives -- 18. Proteolytic ubiquitin like proteins -- 19. C.albicans aspartic proteases: role of these enzymes in degradation of crucial human host proteins at the place of infection and a possible implications of the protease action for propagation of infection. -- 20. MMPs in cancer -- 21. Pathophysiological roles played by proteases of Psedomonas aeruginosa: crucial multifunctional molecules involved in the host infection -- 22. Role of proteases on activating cell death pathways -- 23. varying faces of matrix metalloproteinases in cardiovascular diseases -- 24. kallikreins and kallikrein related peptides (KLKs) in health and disease -- 25. Endogenous proteases in tumoral progression.
000796344 506__ $$aAccess limited to authorized users.
000796344 520__ $$aThis book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
000796344 588__ $$aDescription based on print version record.
000796344 650_0 $$aProteolytic enzymes.
000796344 650_0 $$aDiseases$$xMolecular aspects.
000796344 7001_ $$aChakraborti, Sajal.
000796344 7001_ $$aChakraborti, Tapati.
000796344 7001_ $$aDhalla, Naranjan S.
000796344 77608 $$iPrint version:$$z9811031614$$z9789811031618$$w(OCoLC)961003747
000796344 852__ $$bebk
000796344 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-10-3162-5$$zOnline Access$$91397441.1
000796344 909CO $$ooai:library.usi.edu:796344$$pGLOBAL_SET
000796344 980__ $$aEBOOK
000796344 980__ $$aBIB
000796344 982__ $$aEbook
000796344 983__ $$aOnline
000796344 994__ $$a92$$bISE