000796535 000__ 04428cam\a2200493M\\4500 000796535 001__ 796535 000796535 005__ 20230306143534.0 000796535 006__ m\\\\\o\\d\\\\\\\\ 000796535 007__ cr\un\nnnunnun 000796535 008__ 170728s2017\\\\sz\\\\\\o\\\\\000\0\eng\d 000796535 019__ $$a995163500$$a996409564$$a999476491 000796535 020__ $$a9783319573632$$q(electronic book) 000796535 020__ $$a3319573632$$q(electronic book) 000796535 020__ $$z9783319573625 000796535 020__ $$z3319573624 000796535 035__ $$aSP(OCoLC)ocn995774036 000796535 035__ $$aSP(OCoLC)995774036$$z(OCoLC)995163500$$z(OCoLC)996409564$$z(OCoLC)999476491 000796535 040__ $$aYDX$$beng$$cYDX$$dN$T$$dEBLCP$$dGW5XE$$dN$T$$dUAB 000796535 049__ $$aISEA 000796535 050_4 $$aQM451 000796535 08204 $$a573.8/33$$223 000796535 08204 $$a610 000796535 24500 $$aDecoding neural circuit structure and function :$$bcellular dissection using genetic model organisms /$$cArzu Çelik, Mathias F. Wernet, editors. 000796535 260__ $$aCham :$$bSpringer,$$c2017. 000796535 300__ $$a1 online resource. 000796535 336__ $$atext$$btxt$$2rdacontent 000796535 337__ $$acomputer$$bc$$2rdamedia 000796535 338__ $$aonline resource$$bcr$$2rdacarrier 000796535 5050_ $$aForeword; We Live in Exciting Times; Contents; Notes from the Editors; Anatomy: High-Resolution Neuroanatomy Using Molecular-Genetic Tools; 1 The Current State of the Neuroanatomy Toolkit in the Fruit Fly Drosophila melanogaster; Abstract; 1.1 Introduction; 1.2 Binary Activation Systems; 1.2.1 The GAL4 System; 1.2.2 The LexA System; 1.2.3 The Q System; 1.3 Neurogenetic Labeling; 1.3.1 Fluorescent Protein Reporters; 1.3.2 Non-fluorescent Protein Reporters; 1.4 Regulating Binary Activators; 1.4.1 Enhancer Trapping and Bashing; 1.4.2 Promoter Bashing and Trapping; 1.4.3 Protein Trapping 000796535 5058_ $$a1.5 Refining Genetic Targeting by Intersectional Perturbations1.5.1 OR Gates; 1.5.2 AND Gates; 1.5.3 NOT Gates; 1.5.4 Combinatorial AND/NOT Gating; 1.6 Mitotic Analysis and Multicolor Stochastic Labeling Strategies in D. melanogaster; 1.7 Conclusions and Future Directions; Acknowledgements; References; 2 Retinal Connectomics; Abstract; 2.1 Introduction; 2.2 Some Basic Retinal Anatomy; 2.3 Why Is Retinal Connectomics Difficult?; 2.4 The Long Overdue Automation of Electron Microscopy; 2.5 The Real Bottleneck-Data Analysis; 2.6 A Retinal 'Contactome' 000796535 5058_ $$a2.7 Correlating Retinal Structure with Function2.8 Species-Dependent Differences in Retinal Wiring; 2.9 Future of Retinal Connectomics; References; 3 Recent Progress in the 3D Reconstruction of Drosophila Neural Circuits; Abstract; 3.1 Introduction; 3.1.1 The Fly CNS as a Model System of Connectomics Study; 3.1.2 Anatomy of the Drosophila CNS; 3.2 Reconstruction of Neuronal Circuits and Analysis Using CLSM Image Data; 3.2.1 Visualizing Neurons with Confocal Laser Microscopy; 3.2.2 Three-Dimensional Reconstruction of Neurons in the Fly Brain 000796535 5058_ $$a3.2.2.1 Algorithms for Three-Dimensional Reconstruction3.2.2.2 FluoRender: A Volume Rendering Tool Optimized for CLSM Volume Data; 3.2.3 3D Registration of Brains; 3.2.4 Application of 3D Reconstruction and Registration; 3.2.4.1 Clonal Unit Analysis; 3.2.4.2 Prediction of Synaptic Partners; 3.3 Electron Microscopy-Based Reconstruction and Connectomics; 3.3.1 Ultrastructures Visualized with EM; 3.3.2 Strategies of 3D Reconstruction; 3.3.2.1 Dense (Saturated) Reconstruction/Sparse Reconstruction; 3.3.2.2 Volumetric Reconstruction/Skeletonized Reconstruction 000796535 5058_ $$a3.3.2.3 Manual Tracing/Automatic Tracing3.3.3 3D EM Methods in Connectomics Studies of Drosophila CNS; 3.3.3.1 Serial-Section Transmission EM (ssTEM); 3.3.3.2 Serial Block-Face Scanning EM (SBF-SEM); 3.3.3.3 Focused-Ion Beam-Aided Scanning EM (FIB-SEM); 3.3.4 EM Connectomics Studies in the Fly CNS; 3.3.4.1 Connectivity Analysis in the Optic Lobe Neuropils Using ssTEM and FIB-SEM Methods; 3.3.4.2 Imaging the Blowfly Brain with SBF-SEM; 3.3.4.3 Reconstruction of the Larval CNS with ssTEM; 3.3.5 Other Imaging Techniques for Large-Scale Connectomics 000796535 506__ $$aAccess limited to authorized users. 000796535 588__ $$aDescription based on print version record. 000796535 650_0 $$aNeuroanatomy. 000796535 650_0 $$aNeural circuitry. 000796535 7001_ $$aCelik, Arzu. 000796535 7001_ $$aWernet, Mathias F. 000796535 77608 $$iPrint version:$$z9783319573625$$z3319573624$$w(OCoLC)981117475 000796535 852__ $$bebk 000796535 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-57363-2$$zOnline Access$$91397441.1 000796535 909CO $$ooai:library.usi.edu:796535$$pGLOBAL_SET 000796535 980__ $$aEBOOK 000796535 980__ $$aBIB 000796535 982__ $$aEbook 000796535 983__ $$aOnline 000796535 994__ $$a92$$bISE