Interchangeable Role of the Perivascular Microenvironment: Fostering Tumor Cell Dormancy and Malignancy The Perivascular Microenvironment; Endothelial-Derived Cues Instruct Organogenesis; The Endothelium During Homeostasis and in Wound-Healing; A Perivascular Niche for Stem Cells, Across Tissues; The Endothelium and Tumor Cell Dormancy; Remodeling or Activated Endothelium and Metastatic Colonization; Perspectives and Conclusions; References; Chapter 3: Tissue-Based Biomarkers of Tumor-Vascular Interactions; Introduction; Markers of Angiogenesis; Microvessel Density

Vascular Proliferation Vascular Maturation; Glomeruloid Microvascular Proliferation; Other Vascular Patterns; Vascular Immunomarkers; Markers of Vascular Invasion; Concluding Remarks; References; Chapter 4: Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?; Introduction; The Extracellular Matrix of the Tumor Stroma; Fibrillar Collagens in the Stroma; Fibrillar Collagen Types in the Tumor Stroma; Role of the Stromal Collagens in Tumorigenesis; Collagens Affecting Tumor Cell Growth; Collagens Affecting Cell Migration; Collagen Stiffness Regulating Tumor Growth

Methods for Measuring Fibrillar Collagen Stiffness Role of Fibronectin EDA in the Tumor Stroma; Function of Fibronectin EDA Domain in Wound Healing; Function of Fibronectin EDA Domain in Fibrosis; Function of Fibronectin EDA Domain in Tumorigenesis; Stromal Proteoglycans; Syndecans; Small Leucine-Rich Proteoglycans; Matricellular Proteins: Tenascins and Periostin; Tenascins; Periostin; Summary; References; Chapter 5: Stromal PDGF Receptors as Prognostic and Predictive Biomarkers; Introduction; Molecular Cell Biology of the PDGF System; PDGFs and Their Receptors