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Preface; Contents; Chapter 1: The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5; 1.1 The Function and Composition of the Extracellular Matrix; 1.2 The Role of the ECM in Tumor Development with Emphasis on FN; 1.3 Matricellular Proteins: Extracellular Modulators of the ECM; 1.4 Fibulin-5; 1.4.1 Fbln5 in Cell Adhesion/Migration; 1.4.2 Fbln5 in Proliferation/Survival; 1.4.3 Fbln5 in Angiogenesis; 1.4.4 Fbln5 in Tumor Progression; 1.5 Conclusion; References; Chapter 2: Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer
2.1 Collagen Degradation in Cancer2.2 Extracellular Collagen Degradation; 2.3 Intracellular Collagen Degradation; 2.3.1 The Collagen Internalization Receptor uPARAP/Endo180; 2.3.2 The Collagen Internalization Receptor MR; 2.4 Intracellular Collagen Degradation In Vivo; 2.4.1 Imaging Collagen Internalization In Vivo; 2.4.2 Intracellular Collagen Degradation in Cancer; References; Chapter 3: Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression; 3.1 Structure, Function, and Regulation of Lumican; 3.2 Lumican Implications in Cancer; 3.2.1 Breast Cancer
3.2.2 Colorectal Cancer3.2.3 Lung Cancer; 3.2.4 Pancreatic Cancer; 3.3 Drug Delivery in Cancer and Its Association with Lumican Expression; 3.3.1 Collagen Organization in Tumors; 3.3.2 VEGF and PDGF; 3.4 Summary; References; Chapter 4: Versican: Role in Cancer Tumorigenesis; 4.1 Introduction; 4.2 Source of Versican in Cancer; 4.3 The Role of Versican in Cancer; 4.4 The Regulation of Versican Expression in Cancer; 4.5 Versican as a Diagnostic and Prognostic Marker in Cancer; 4.6 Versican in LMS: Our Experience; 4.7 Conclusions; References
Chapter 5: Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials5.1 Introduction; 5.2 The Role of the Microenvironment in GBM Malignancy; 5.2.1 ECM; 5.3 Engineering Advanced Models of the GBM Microenvironment; 5.3.1 Traditional Culture Systems; 5.3.2 Polymer-Based 3D Matrices; 5.3.3 Microfabricated Platforms; 5.3.4 Molecular Discovery and Screening; 5.4 Future Directions; 5.5 Conclusions; References; Chapter 6: Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way; 6.1 Introduction; 6.2 Breaching the BM De Novo: AC Invasion
6.2.1 Transcription Factors Promoting Invasion6.2.2 Establishing the Invasive Cell Membrane; 6.2.3 AC Invadopodia and the Invasive Protrusion: Breaching and Clearing the BM; 6.3 Post AC Invasion: BM Sliding Further Opens the Breach; 6.4 AC Invasion and SPARC: A Model for the Tumor Microenvironment; 6.5 Summary and Perspective; References
2.1 Collagen Degradation in Cancer2.2 Extracellular Collagen Degradation; 2.3 Intracellular Collagen Degradation; 2.3.1 The Collagen Internalization Receptor uPARAP/Endo180; 2.3.2 The Collagen Internalization Receptor MR; 2.4 Intracellular Collagen Degradation In Vivo; 2.4.1 Imaging Collagen Internalization In Vivo; 2.4.2 Intracellular Collagen Degradation in Cancer; References; Chapter 3: Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression; 3.1 Structure, Function, and Regulation of Lumican; 3.2 Lumican Implications in Cancer; 3.2.1 Breast Cancer
3.2.2 Colorectal Cancer3.2.3 Lung Cancer; 3.2.4 Pancreatic Cancer; 3.3 Drug Delivery in Cancer and Its Association with Lumican Expression; 3.3.1 Collagen Organization in Tumors; 3.3.2 VEGF and PDGF; 3.4 Summary; References; Chapter 4: Versican: Role in Cancer Tumorigenesis; 4.1 Introduction; 4.2 Source of Versican in Cancer; 4.3 The Role of Versican in Cancer; 4.4 The Regulation of Versican Expression in Cancer; 4.5 Versican as a Diagnostic and Prognostic Marker in Cancer; 4.6 Versican in LMS: Our Experience; 4.7 Conclusions; References
Chapter 5: Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials5.1 Introduction; 5.2 The Role of the Microenvironment in GBM Malignancy; 5.2.1 ECM; 5.3 Engineering Advanced Models of the GBM Microenvironment; 5.3.1 Traditional Culture Systems; 5.3.2 Polymer-Based 3D Matrices; 5.3.3 Microfabricated Platforms; 5.3.4 Molecular Discovery and Screening; 5.4 Future Directions; 5.5 Conclusions; References; Chapter 6: Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way; 6.1 Introduction; 6.2 Breaching the BM De Novo: AC Invasion
6.2.1 Transcription Factors Promoting Invasion6.2.2 Establishing the Invasive Cell Membrane; 6.2.3 AC Invadopodia and the Invasive Protrusion: Breaching and Clearing the BM; 6.3 Post AC Invasion: BM Sliding Further Opens the Breach; 6.4 AC Invasion and SPARC: A Model for the Tumor Microenvironment; 6.5 Summary and Perspective; References