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Preface; Contents; Part I: Immunology; Chapter 1: Notch Ligands for Lymphocyte Development; 1.1 Introduction; 1.2 General Information of Notch Ligands; 1.2.1 Basic Structure; 1.2.2 Endocytosis of Notch Ligand Is Essential for Signal Induction; 1.2.3 Preferential Interaction with Fringe-Modified Notch; 1.3 Notch Ligand in the Bone Marrow; 1.3.1 Jag1-Mediated Notch Signaling for the Maintenance of Hematopoietic Stem Cells; 1.3.2 Dll4-Induced Weak Notch Signaling Is Present in the BM; 1.4 Notch Ligand in the Thymus; 1.4.1 The Indispensable Role of Dll4 for the Determination of T Cell Fate
1.4.2 Dll4 Is Required for Further Developmental Processes1.5 Notch Ligand in Secondary Lymphoid Organs; 1.5.1 Spleen; 1.5.2 Lymph Node; 1.5.3 Antigen-Presenting Cells; 1.6 Concluding Remarks; References; Chapter 2: Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells; 2.1 Introduction; 2.2 Notch Signaling in CD4/CD8 Lineage Choice in Developing T Cells; 2.3 Notch Signaling in Controlling T Cell Cytotoxicity; 2.4 Notch Signaling in the Choice of CD8 T Cells to Effector or Memory; 2.5 Notch Signaling as a Therapeutic Target for Clinical Disorders
2.6 Tumor Cells Suppress Notch Signaling in CD8 T Cells to Escape Immunosurveillance2.7 Concluding Remarks; References; Chapter 3: Notch and Myeloid Cells; 3.1 Introduction; 3.2 The Ontology of Dendritic Cells and Their Differentiation Is Regulated by Notch Signaling; 3.3 DC Function; 3.4 Monocyte Development; 3.5 Macrophage Differentiation; 3.6 Macrophage Polarization; 3.7 Cross Talk with TLR Signaling; 3.8 Macrophage Function; 3.9 Conclusions; References; Chapter 4: Taking CD4 T Cells Up a Notch; 4.1 Introduction; 4.2 The Notch Pathway in a Nutshell
4.3 T Helper Cell Activation, Survival, and Memory4.4 T Helper Cell Differentiation and Notch; 4.4.1 Th1 Cell Differentiation; 4.4.2 Th2 and Th9 Cell Differentiation; 4.4.3 Th17 and Th22 Cell Differentiation; 4.4.4 Tfh Cell Differentiation; 4.5 Tolerogenic T Cells; 4.6 Concluding Remarks; References; Part II: Cancer; Chapter 5: NOTCH in Malignant Lymphoma; 5.1 Introduction; 5.2 Genetic Aberrations of NOTCH Genes in Mature B-Cell Neoplasms: Prologue; 5.3 NOTCH1 Mutations in Chronic Lymphocytic Leukemia; 5.4 Mutations of NOTCH2 and Other NOTCH Pathway Genes in Splenic Marginal Zone Lymphoma
5.5 NOTCH1 and NOTCH2 Mutations in Mantle Cell Lymphoma5.6 NOTCH Pathway Gene Mutations in Diffuse Large B-Cell Lymphoma; 5.7 NOTCH Pathway Gene Mutations in Other Mature B-Cell Neoplasms; 5.8 Perspectives and Speculations; 5.8.1 Physiologic NOTCH Signaling in Mature B Cells.; 5.8.2 NOTCH Signaling in B-Cell Activation; 5.8.3 NOTCH Signaling and Epigenetic Regulation; 5.8.4 NOTCH Signaling and Tumor Microenvironment; 5.8.5 Implications in Clinical Settings; References; Chapter 6: The Two Faces of Notch in Solid Cancers; 6.1 Cancers Associated with Active Notch Signalling
1.4.2 Dll4 Is Required for Further Developmental Processes1.5 Notch Ligand in Secondary Lymphoid Organs; 1.5.1 Spleen; 1.5.2 Lymph Node; 1.5.3 Antigen-Presenting Cells; 1.6 Concluding Remarks; References; Chapter 2: Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells; 2.1 Introduction; 2.2 Notch Signaling in CD4/CD8 Lineage Choice in Developing T Cells; 2.3 Notch Signaling in Controlling T Cell Cytotoxicity; 2.4 Notch Signaling in the Choice of CD8 T Cells to Effector or Memory; 2.5 Notch Signaling as a Therapeutic Target for Clinical Disorders
2.6 Tumor Cells Suppress Notch Signaling in CD8 T Cells to Escape Immunosurveillance2.7 Concluding Remarks; References; Chapter 3: Notch and Myeloid Cells; 3.1 Introduction; 3.2 The Ontology of Dendritic Cells and Their Differentiation Is Regulated by Notch Signaling; 3.3 DC Function; 3.4 Monocyte Development; 3.5 Macrophage Differentiation; 3.6 Macrophage Polarization; 3.7 Cross Talk with TLR Signaling; 3.8 Macrophage Function; 3.9 Conclusions; References; Chapter 4: Taking CD4 T Cells Up a Notch; 4.1 Introduction; 4.2 The Notch Pathway in a Nutshell
4.3 T Helper Cell Activation, Survival, and Memory4.4 T Helper Cell Differentiation and Notch; 4.4.1 Th1 Cell Differentiation; 4.4.2 Th2 and Th9 Cell Differentiation; 4.4.3 Th17 and Th22 Cell Differentiation; 4.4.4 Tfh Cell Differentiation; 4.5 Tolerogenic T Cells; 4.6 Concluding Remarks; References; Part II: Cancer; Chapter 5: NOTCH in Malignant Lymphoma; 5.1 Introduction; 5.2 Genetic Aberrations of NOTCH Genes in Mature B-Cell Neoplasms: Prologue; 5.3 NOTCH1 Mutations in Chronic Lymphocytic Leukemia; 5.4 Mutations of NOTCH2 and Other NOTCH Pathway Genes in Splenic Marginal Zone Lymphoma
5.5 NOTCH1 and NOTCH2 Mutations in Mantle Cell Lymphoma5.6 NOTCH Pathway Gene Mutations in Diffuse Large B-Cell Lymphoma; 5.7 NOTCH Pathway Gene Mutations in Other Mature B-Cell Neoplasms; 5.8 Perspectives and Speculations; 5.8.1 Physiologic NOTCH Signaling in Mature B Cells.; 5.8.2 NOTCH Signaling in B-Cell Activation; 5.8.3 NOTCH Signaling and Epigenetic Regulation; 5.8.4 NOTCH Signaling and Tumor Microenvironment; 5.8.5 Implications in Clinical Settings; References; Chapter 6: The Two Faces of Notch in Solid Cancers; 6.1 Cancers Associated with Active Notch Signalling