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Table of Contents
Author Contributions; Foreword; Preface; Abbreviations; Contents; Chapter 1: Introduction to Budget-Impact Analysis; 1.1 What Is Budget-Impact Analysis?; 1.2 Budget-Impact Analyses Compared with Cost-Effectiveness Analyses; 1.3 Uses of Budget-Impact Analyses; 1.4 Guidelines for Budget-Impact Analyses; 1.5 Overview of Chapters in This Book; Exercises; References; Chapter 2: Determining the Analytic Framework; 2.1 Eligible Population in Jurisdiction; 2.1.1 Impact of Positioning of the New Drug Within the Current Treatment Pathway on Eligible Population Size
2.1.2 Impact of Regulatory Approval on Eligible Population Size2.1.3 Impact of Reimbursement Decisions on Eligible Population Size; 2.1.4 Impact of New Drug Attributes on Initial Population Size; 2.1.5 Impact of New Drug Attributes on Population Size Over Model Time Horizon; 2.2 Budget Holder Time Horizon; 2.3 Potential Use of the New Drug Within the Treatment Mix; 2.4 Budget Holder Cost Perspective; 2.4.1 Service Delivery Cost Versus Reimbursement Rate; 2.4.2 Fixed Versus Variable Costs; 2.4.3 Cost Categories of Interest; 2.5 Compilation of Analytic Framework; Exercises; References
Chapter 3: Estimating the Diagnosed, Treated, and Eligible Population3.1 Incident and Prevalent Populations; 3.2 Estimating the Eligible Population Size; 3.3 Data for Identifying the Eligible Population; 3.4 Estimating Population Size by Subgroup; 3.5 Changing Size of the Eligible Population Over the Analysis Time Horizon; 3.5.1 Changing Population Size Regardless of Introduction of the New Drug; 3.5.2 Changing Population Size and Condition Severity Mix due to the Introduction of the New Drug; 3.6 Including Catch-Up Effects for the Prevalent Population
3.7 Which Eligible Population Should We Include in the Budget-Impact Analysis?Exercises; References; Chapter 4: Estimating the Treatment Mix; 4.1 Treatment Shares Without the New Drug in the Treatment Mix; 4.2 Treatment Shares with the New Drug in the Treatment Mix; 4.3 Which Treatment Shares Should We Include in the Budget-Impact Analysis?; Exercises; Reference; Chapter 5: Estimating Treatment-Related Costs; 5.1 Costs for Drug Acquisition; 5.1.1 Co-payments and Coinsurance; 5.1.2 Dispensing Fees; 5.1.3 Dose Levels; 5.1.4 Duration of Treatment; 5.2 Costs for Administering the Drug
5.3 Costs for Diagnostic Tests to Determine Eligibility for the Drug5.4 Costs for Monitoring the Drug for Safety and Efficacy; 5.5 Costs for Treating Side Effects Associated with the Drug; 5.6 Accounting for Differing Treatment Costs in the First and Subsequent Treatment Years; 5.7 Accounting for Other Treatment Costs; 5.8 Estimating Resource Use Changes with the New Drug; Exercises; References; Chapter 6: Estimating Condition-Related Costs; 6.1 Why the New Drug Might Change Condition-Related Costs; 6.2 Estimating Changes in Condition-Related Costs for Incident Populations; 6.2.1 Acute Conditions or Chronic Conditions Where Changes Occur Almost Immediately.
2.1.2 Impact of Regulatory Approval on Eligible Population Size2.1.3 Impact of Reimbursement Decisions on Eligible Population Size; 2.1.4 Impact of New Drug Attributes on Initial Population Size; 2.1.5 Impact of New Drug Attributes on Population Size Over Model Time Horizon; 2.2 Budget Holder Time Horizon; 2.3 Potential Use of the New Drug Within the Treatment Mix; 2.4 Budget Holder Cost Perspective; 2.4.1 Service Delivery Cost Versus Reimbursement Rate; 2.4.2 Fixed Versus Variable Costs; 2.4.3 Cost Categories of Interest; 2.5 Compilation of Analytic Framework; Exercises; References
Chapter 3: Estimating the Diagnosed, Treated, and Eligible Population3.1 Incident and Prevalent Populations; 3.2 Estimating the Eligible Population Size; 3.3 Data for Identifying the Eligible Population; 3.4 Estimating Population Size by Subgroup; 3.5 Changing Size of the Eligible Population Over the Analysis Time Horizon; 3.5.1 Changing Population Size Regardless of Introduction of the New Drug; 3.5.2 Changing Population Size and Condition Severity Mix due to the Introduction of the New Drug; 3.6 Including Catch-Up Effects for the Prevalent Population
3.7 Which Eligible Population Should We Include in the Budget-Impact Analysis?Exercises; References; Chapter 4: Estimating the Treatment Mix; 4.1 Treatment Shares Without the New Drug in the Treatment Mix; 4.2 Treatment Shares with the New Drug in the Treatment Mix; 4.3 Which Treatment Shares Should We Include in the Budget-Impact Analysis?; Exercises; Reference; Chapter 5: Estimating Treatment-Related Costs; 5.1 Costs for Drug Acquisition; 5.1.1 Co-payments and Coinsurance; 5.1.2 Dispensing Fees; 5.1.3 Dose Levels; 5.1.4 Duration of Treatment; 5.2 Costs for Administering the Drug
5.3 Costs for Diagnostic Tests to Determine Eligibility for the Drug5.4 Costs for Monitoring the Drug for Safety and Efficacy; 5.5 Costs for Treating Side Effects Associated with the Drug; 5.6 Accounting for Differing Treatment Costs in the First and Subsequent Treatment Years; 5.7 Accounting for Other Treatment Costs; 5.8 Estimating Resource Use Changes with the New Drug; Exercises; References; Chapter 6: Estimating Condition-Related Costs; 6.1 Why the New Drug Might Change Condition-Related Costs; 6.2 Estimating Changes in Condition-Related Costs for Incident Populations; 6.2.1 Acute Conditions or Chronic Conditions Where Changes Occur Almost Immediately.