Linked e-resources
Details
Table of Contents
Encapsulating Islets: Biomass Considerations Islet Encapsulation Failure Modes;Subacute Processing Stress; Acute Implant Failure; Chronic Failure of Cell Encapsulation Systems; Immune Rejection; Hypoxia; Strategies for Addressing Hypoxia; Refillable Gas Supply; Artificial Oxygen Carriers; Vascularization; Strategies for Mitigating Chronic Fibrosis; Coatings and Covalent Modifications; Stem Cell-Derived B-Cells as an Alternative to Isolated Cadaveric Islets; Generation of Glucoresponsive Stem Cell-Derived B-Cells; Clinical Translation of Stem Cell-Derived B-Cells
The Future of B-Cell TherapyReferences; 3: Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases; Introduction; Acute Pathology of Stroke and TBI; Chronic Pathology of Stroke and TBI; Stem Cell Therapy for Neurovascular Disorders; Stem Cell Transplantation in Stroke; Stem Cell Transplantation in TBI; Mechanisms of Stem Cell Therapy; The Promise of Combination Therapies with Stem Cells; The Spleen as a Novel Target for Stem Cells; Challenges in Stem Cell Therapy; Potential Adverse Effects of Stem Cell Therapy; Cell-Free Materials and Exosomes in Neurovascular Therapy
Dedication; Preface: A Brief Introduction to the Span of Cell Therapy; Contents; Contributors; 1: Molecular Considerations in Cell Transplant Imaging; Introduction; The Need for Molecular Imaging: Limitations of Cell-Based Therapies;Recent Advances in Molecular Imaging;Bright-Field and Fluorescent Optical Imaging; PET Imaging; Bioluminescence Imaging; MR Imaging and Spectroscopy; Concluding Remarks and Outlook; References; 2: Considerations for Successful Encapsulated B-cell Therapy; Introduction; Islet Transplantation; Islet Transplantation: Site Selection Considerations
TBI and Stroke: Implications of Cell-Free Treatment Feasibility of Exosome Transplantation Therapies; Conclusion: Connecting the Dots of Stem Cell Therapy; References; 4: Cell Replacement Strategies for Parkinson's Disease; Introduction; Ventral Mesencephalon Grafting; Clinical Trial Outcomes; Stem Cell Grafting; Conclusions; References; 5: Cell Therapy for Epilepsy; Epilepsy; History; Definitions, Clinical Features, Therapeutic Needs, and Models; Cell Therapy: Direct Grafting; Introduction: Cell Types; Substitution Strategies and Bystander Effects
Increased Inhibition Strategies Limits of This Approach; Cell Therapy: Encapsulated Cell Biodelivery (ECB) Systems; Introduction: Description of the Strategy; Increased Inhibition Strategies: Galanin; Neurotrophic Factors; Delivering NTF with ECB Devices; References; 6: Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions; Introduction; Dendritic Cell Subpopulations; Plasmacytoid Dendritic Cells; Conventional/Myeloid Dendritic Cells; Skin Dendritic Cells; Inflammatory DCs; Dendritic Cell Functions; Activating Signals from DCs; Inhibitory Signals from DCs
The Future of B-Cell TherapyReferences; 3: Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases; Introduction; Acute Pathology of Stroke and TBI; Chronic Pathology of Stroke and TBI; Stem Cell Therapy for Neurovascular Disorders; Stem Cell Transplantation in Stroke; Stem Cell Transplantation in TBI; Mechanisms of Stem Cell Therapy; The Promise of Combination Therapies with Stem Cells; The Spleen as a Novel Target for Stem Cells; Challenges in Stem Cell Therapy; Potential Adverse Effects of Stem Cell Therapy; Cell-Free Materials and Exosomes in Neurovascular Therapy
Dedication; Preface: A Brief Introduction to the Span of Cell Therapy; Contents; Contributors; 1: Molecular Considerations in Cell Transplant Imaging; Introduction; The Need for Molecular Imaging: Limitations of Cell-Based Therapies;Recent Advances in Molecular Imaging;Bright-Field and Fluorescent Optical Imaging; PET Imaging; Bioluminescence Imaging; MR Imaging and Spectroscopy; Concluding Remarks and Outlook; References; 2: Considerations for Successful Encapsulated B-cell Therapy; Introduction; Islet Transplantation; Islet Transplantation: Site Selection Considerations
TBI and Stroke: Implications of Cell-Free Treatment Feasibility of Exosome Transplantation Therapies; Conclusion: Connecting the Dots of Stem Cell Therapy; References; 4: Cell Replacement Strategies for Parkinson's Disease; Introduction; Ventral Mesencephalon Grafting; Clinical Trial Outcomes; Stem Cell Grafting; Conclusions; References; 5: Cell Therapy for Epilepsy; Epilepsy; History; Definitions, Clinical Features, Therapeutic Needs, and Models; Cell Therapy: Direct Grafting; Introduction: Cell Types; Substitution Strategies and Bystander Effects
Increased Inhibition Strategies Limits of This Approach; Cell Therapy: Encapsulated Cell Biodelivery (ECB) Systems; Introduction: Description of the Strategy; Increased Inhibition Strategies: Galanin; Neurotrophic Factors; Delivering NTF with ECB Devices; References; 6: Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions; Introduction; Dendritic Cell Subpopulations; Plasmacytoid Dendritic Cells; Conventional/Myeloid Dendritic Cells; Skin Dendritic Cells; Inflammatory DCs; Dendritic Cell Functions; Activating Signals from DCs; Inhibitory Signals from DCs