Abbreviations; Chapter 1: Anatomy and Pathophysiology of Retinal Pigment Epithelial Detachment; 1.1 Introduction; 1.2 The Retinal Pigment Epithelium: Interface Between Blood and Photoreceptors; 1.3 Function of the RPE; 1.4 Mechanisms of Adherence Between RPE and Photoreceptors in Health and Disease; 1.4.1 Basic Mechanisms in Health; 1.4.2 Transepithelial Transport in Disease; 1.5 Causes Leading to RPE Detachment; 1.5.1 Changes in Bruch's Membrane and in Sub-pigment-­Epithelial Space; 1.5.2 Changes in Choroid and Choriocapillaris

1.6 The Effect of RPE Detachment: Mesenchymal Transdifferentiation of the RPE1.7 Summary; References; Chapter 2: Imaging in Retinal Pigment Epithelial Detachment; 2.1 Introduction; 2.2 Angiography; 2.2.1 Fluorescein Angiography; 2.2.2 Indocyanine Green Angiography; 2.2.3 Angiography Summary; 2.3 Spectral Domain Optical Coherence Tomography; 2.3.1 SD-OCT Summary; 2.4 OCT-Angiography; 2.4.1 OCTA Summary; 2.5 Autofluorescence; 2.5.1 Fundus Autofluorescence; 2.5.2 Near-Infrared Autofluorescence; 2.5.3 Autofluorescence Summary; 2.6 Spectral Reflectance Imaging; 2.6.1 Blue Reflectance

2.6.2 Green Reflectance2.6.3 Near-Infrared Reflectance; 2.6.4 Multi-Color Scanning Laser Imaging; 2.6.5 Spectral Reflectance Imaging Summary; 2.7 Summary; Chapter 3: Retinal Pigment Epithelial Detachment in Age-Related Macular Degeneration; 3.1 Introduction; 3.2 Epidemiology; 3.3 Pathogenesis; 3.4 Clinical Examination; 3.5 Imaging; 3.6 Drusenoid PED; 3.7 Serous PED; 3.8 Vascularized and Fibrovascular PED; 3.9 Natural Course; 3.10 Therapy; 3.11 Differential Diagnosis; 3.12 Summary; References; Chapter 4: Drusenoid Retinal Pigment Epithelial Detachment; 4.1 Introduction

4.2 Classification and Definition4.3 Epidemiology; 4.4 Pathogenesis; 4.5 Clinical Examination; 4.5.1 Stereoscopic Funduscopy; 4.6 Imaging; 4.6.1 Optical Coherence Tomography; 4.6.2 Fundus Autofluorescence Imaging; 4.6.3 Fluorescein Angiography; 4.6.4 Indocyanine Green Angiography; 4.7 Natural History; 4.8 Therapeutic Intervention; 4.9 Differential Diagnosis of Drusenoid PED; 4.10 Summary; References; Chapter 5: Retinal Pigment Epithelial Detachment in Retinal Angiomatous Proliferation; 5.1 Introduction; 5.2 Epidemiology; 5.3 Pathogenesis; 5.4 Clinical Examination; 5.5 Imaging

5.5.1 Fluorescein Angiography5.5.2 ICGA; 5.5.3 OCT; 5.6 Natural History; 5.7 Therapy; 5.8 Differential Diagnosis; 5.9 Summary; References; Chapter 6: Retinal Pigment Epithelial Detachment in Polypoidal Choroidal Vasculopathy; 6.1 Introduction; 6.1.1 Epidemiology; 6.1.2 Pathogenesis; 6.1.3 Histopathology; 6.1.4 Clinical Examination; 6.2 Imaging; 6.2.1 Imaging of PCV in ICGA; 6.2.2 Imaging of PCV in OCT; 6.3 Natural History; 6.4 Therapy; 6.4.1 Laser Treatment (Photocoagulation):; 6.4.2 PDT; 6.4.3 Anti-VEGF Treatment; 6.4.4 Combination Treatment (vPDT and anti-VEGF); 6.5 Differential Diagnosis