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000798420 019__ $$a1003203184$$a1003256021
000798420 020__ $$a9783319601748$$q(electronic book)
000798420 020__ $$a3319601741$$q(electronic book)
000798420 020__ $$z9783319601724
000798420 020__ $$z3319601725
000798420 035__ $$aSP(OCoLC)on1003117500
000798420 035__ $$aSP(OCoLC)1003117500$$z(OCoLC)1003203184$$z(OCoLC)1003256021
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000798420 049__ $$aISEA
000798420 050_4 $$aQP552.G16
000798420 08204 $$a572/.6$$223
000798420 24500 $$aG-protein-coupled receptor dimers /$$cKatharine Herrick-Davis, Graeme Milligan, Giuseppe Di Giovanni, editors.
000798420 264_1 $$aCham, Switzerland :$$bHumana Press,$$c[2017].
000798420 264_4 $$c©2017
000798420 300__ $$a1 online resource.
000798420 336__ $$atext$$btxt$$2rdacontent
000798420 337__ $$acomputer$$bc$$2rdamedia
000798420 338__ $$aonline resource$$bcr$$2rdacarrier
000798420 4901_ $$aThe receptors ;$$vv. 33
000798420 504__ $$aIncludes bibliographical references.
000798420 5050_ $$aDedication; Foreword; On the Question of GPCR Oligomerization; References; Preface; Contents; Part I: Introduction; Chapter 1: Historical Perspectives: From Monomers to Dimers and Beyond, an Exciting Journey in the World of G Protein-Coupled Receptors; 1.1 Introduction; 1.2 The Birth of the Dimerization Concept; 1.3 Establishing the New Concept; 1.4 Oligomers Make the Picture More Complicated; 1.5 Receptor Homo- and Heteromers as New Pharmacological Targets; 1.6 Perspectives; References
000798420 5058_ $$aChapter 2: The Use of Spatial Intensity Distribution Analysis to Examine G Protein-Coupled Receptor Oligomerization2.1 Introduction; 2.1.1 SpIDA Procedure; 2.1.2 Choice of Fluorophore; 2.1.3 Selection of the Expression System; 2.1.4 Establishing Imaging Conditions for SpIDA; 2.1.4.1 Laser Power Intensity Measurement; 2.1.4.2 Laser Spot Beam Waist Radius Size; 2.1.4.3 Analog Detector Calibration; 2.1.4.4 Assessment of White Noise Level; 2.1.5 Laser Scanning Confocal Image Acquisition; 2.1.6 Spatial Intensity Distribution Analysis of Laser Scanning Confocal Images
000798420 5058_ $$a2.1.6.1 Determining the Monomeric Quantal Brightness Value2.1.6.2 1 Population or 2 Population Mode; 2.1.6.3 When Does a QB Value Reflect Monomeric and When Dimeric/Oligomeric States?; 2.1.7 Determining the Quaternary Structure of GPCRs and How This May Be Affected by Ligand Binding; 2.1.8 Future Perspectives of SpIDA; References; Chapter 3: Advanced Microscopy Techniques; 3.1 Introduction; 3.2 FRET-Based Microscopy; 3.2.1 Definitions and the Principle of the Method; 3.2.2 Theoretical Basis of the Method; 3.2.3 Practical Implementation of FRET
000798420 5058_ $$a3.2.3.1 General Requirements for Optical Microscopes Used in FRET Studies3.2.3.2 Two-Photon Absorption Optical Micro-spectroscopy; 3.2.3.3 Determination of FRET Efficiency from Optical Micro-­Spectroscopy Data; 3.2.4 Theoretical Models Used for Information Extraction from Experimental Data; 3.2.4.1 Prediction of FRET Efficiencies for Various Oligomer Configurations; 3.2.4.2 Computation of Average FRET Efficiencies for Mixtures of Oligomers; 3.2.5 Experimental Applications of FRET; 3.2.5.1 FRET Spectrometry; 3.2.5.2 Statistical-Ensemble Approach to FRET
000798420 5058_ $$a3.2.5.3 Combination Between the Two FRET Approaches3.3 Spatial Fluorescence Correlation Spectroscopy; 3.3.1 Principle of the Method; 3.3.1.1 Generalized Spatial Correlation Function; 3.3.1.2 Spatial Auto-Correlation; 3.3.1.3 Spatial Cross-Correlation and Colocalization; 3.3.2 Practical Implementation of ICCS; 3.3.3 Experimental Applications of Spatial Fluorescence Correlation Spectroscopy; 3.4 Temporal Fluorescence Correlation Spectroscopy; 3.4.1 Principle of the Method; 3.4.2 Theoretical Background of the Method; 3.4.2.1 Generalized Temporal Correlation Function
000798420 506__ $$aAccess limited to authorized users.
000798420 588__ $$aDescription based on print version record.
000798420 650_0 $$aG proteins$$xReceptors.
000798420 650_0 $$aDimers.
000798420 7001_ $$aHerrick-Davis, Katharine,$$eeditor.
000798420 7001_ $$aMilligan, Graeme.$$eeditor.
000798420 7001_ $$aDi Giovanni, Giuseppe,$$eeditor.
000798420 77608 $$iPrint version:$$z9783319601724$$z3319601725$$w(OCoLC)987282362
000798420 830_0 $$aReceptors ;$$vv. 33.
000798420 852__ $$bebk
000798420 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-60174-8$$zOnline Access$$91397441.1
000798420 909CO $$ooai:library.usi.edu:798420$$pGLOBAL_SET
000798420 980__ $$aEBOOK
000798420 980__ $$aBIB
000798420 982__ $$aEbook
000798420 983__ $$aOnline
000798420 994__ $$a92$$bISE