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000799725 019__ $$a1003194550
000799725 020__ $$a9783319597867$$q(electronic book)
000799725 020__ $$a3319597868$$q(electronic book)
000799725 020__ $$z9783319597843
000799725 020__ $$z3319597841
000799725 035__ $$aSP(OCoLC)on1003192524
000799725 035__ $$aSP(OCoLC)1003192524$$z(OCoLC)1003194550
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000799725 049__ $$aISEA
000799725 050_4 $$aRC268.4
000799725 08204 $$a616.99/4042$$223
000799725 24500 $$aDNA and histone methylation as cancer targets /$$cAtsushi Kan, Yu-ichi Tsukada, editors.
000799725 264_1 $$aCham, Switzerland :$$bHumana Press,$$c[2017]
000799725 264_4 $$c©2017
000799725 300__ $$a1 online resource :$$billustrations.
000799725 336__ $$atext$$btxt$$2rdacontent
000799725 337__ $$acomputer$$bc$$2rdamedia
000799725 338__ $$aonline resource$$bcr$$2rdacarrier
000799725 4901_ $$aCancer drug discovery and development
000799725 504__ $$aIncludes bibliographical references.
000799725 5050_ $$aForeword; Contents; DNA and Histone Methylation in Epigenetics; 1 Introduction; 2 DNA Methylation; 2.1 DNA Methylation in Mammals; 2.2 DNA Methyltransferase; 2.3 Methylated DNA Binding Protein; 2.4 Function of DNA Methylation; 3 Histone Methylation; 3.1 Methylation Sites; 3.2 Histone Methyltransferases; 3.3 Methylated Histone Binding Protein; 3.4 Function of Histone Methylation; 4 Perspective; References; Part I: DNA Methylation and Cancer; The Molecular Basis of DNA Methylation; 1 Introduction; 2 DNA Methylation and Gene Silencing; 3 DNA Methyltransferases in Mammals
000799725 5058_ $$a3.1 Proposed Mechanism of Methylation Reaction3.2 Establishment of DNA Methylation Patterns; 3.2.1 Properties of the de novo Methyltransferases Dnmt3a and 3b; 3.2.2 Structural Properties of Dnmt3; 3.2.3 Sequence Specificity of de novo Methyltransferases; 3.2.4 Factors that Guide Dnmt3 to Target Sites for Methylation; 3.2.5 Function of Dnmt3L in Establishing DNA Methylation Patterns; 3.2.6 Chromatin Structure and Establishment of DNA Methylation; 3.3 Maintenance DNA Methylation; 3.3.1 Structure and Properties of Dnmt1; 3.3.2 Factors Necessary for Maintenance DNA Methylation
000799725 5058_ $$a3.3.3 Exceptional Expression of Dnmt1 and Its Localization3.4 Cross-Talk Between de novo- and Maintenance-Type DNA Methyltransferases; 4 Modifications of Dnmts; 5 DNA Methylation and Aging; 6 Inhibitors of Dnmts; 7 DNA Demethylation; 8 Perspective; References; The Molecular Basis of DNA Demethylation; 1 Introduction; 2 DNA Methylation Machinery; 3 Passive and Active DNA Demethylation; 4 TET-Mediated Oxidative DNA Demethylation; 4.1 TET Family Dioxygenases; 4.2 TET-Mediated Iterative Oxidation of 5mC; 4.3 TDG-Mediated Excision of 5fC/5caC
000799725 5058_ $$a4.4 Replication-Dependent Dilution of 5mC Oxidation Derivatives4.5 Other Potential TET-Initiated Active DNA Demethylation Pathways; 5 Potential TET-Independent Active DNA Demethylation Mechanisms; 6 Regulation of TET-Mediated DNA Demethylation; 6.1 Regulation of TET Expression; 6.2 Regulation of TET Activity by Metabolites and Nutrients; 6.3 Regulation by TET-Interacting Proteins and DNA-Binding Proteins; 7 Concluding Remarks; References; DNA Methylation Changes in Cancer; 1 Introduction; 2 DNA Methylation Machinery; 3 DNA De-methylation; 4 DNA Modification Perturbations in Cancer
000799725 5058_ $$a5 Discrete Hyper-Methylation Events in Cancer6 Changes to the 5hmC Landscape in Cancer; 7 The Role of the TET Enzymes in Cancer; 8 Indirect Impact of DNA Methylation Reprogramming on Cancer Epigenomes; 9 Future Perspectives; References; Misregulation of DNA Methylation Regulators in Cancer; 1 Introduction; 1.1 Molecular Components of the DNA Epigenetic Pathway: Establishment, Interpretation, and Turnover of DNA Modifications; 1.2 Genome-Wide Variation in DNA Modifications, How They Are Achieved, and Their Functional Interpretation; 2 Cancer: The Result of a Deregulated DNA Methylation Pathway
000799725 506__ $$aAccess limited to authorized users.
000799725 520__ $$aThis book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
000799725 588__ $$aOnline resource; title from PDF title page (viewed September 19, 2017).
000799725 650_0 $$aCancer$$xGenetic aspects.
000799725 650_0 $$aHistones$$xMethylation.
000799725 650_0 $$aEpigenetics.
000799725 650_0 $$aCancer cells.
000799725 7001_ $$aKan, Atsushi,$$eeditor.
000799725 7001_ $$aTsukada, Yu-ichi,$$eeditor.
000799725 77608 $$iPrint version:$$z9783319597843$$z3319597841$$w(OCoLC)985079244
000799725 830_0 $$aCancer drug discovery and development.
000799725 852__ $$bebk
000799725 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-59786-7$$zOnline Access$$91397441.1
000799725 909CO $$ooai:library.usi.edu:799725$$pGLOBAL_SET
000799725 980__ $$aEBOOK
000799725 980__ $$aBIB
000799725 982__ $$aEbook
000799725 983__ $$aOnline
000799725 994__ $$a92$$bISE