Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks
Title
Immune metabolism in health and tumor / Bin Li, Fan Pan, editors.
ISBN
9789402411706 (electronic book)
9402411704 (electronic book)
9789402411683
9402411682
Published
Dordrecht, The Netherlands : Springer, [2017]
Copyright
©2017
Language
English
Description
1online resource (v, 223 pages) : illustrations.
Call Number
QR182
Dewey Decimal Classification
571.9/6
610
Summary
"This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics"--Publisher's description.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from pdf title page (SpringerLink, viewed September 11, 2017).
Series
Advances in experimental medicine and biology ; v. 1011. 0065-2598
Metabolism in immune cell differentiation and function / Nicole M. Chapman, Sharad Shrestha, Hongbo Chi
Metabolic regulation of T cell immunity / Paolo D. A. Vignali, Joseph Barbi, Fan Pan
Transcriptional regulation of T cell metabolism reprograming / Jinxia Zhang, Guoyu Bi, Yu Xia, Pingfei Li, Xiaofei Deng, Zhengping Wei [and others]
Adipose tissue-resident regulatory T cells / Fuxiang Zhu, Aiting Wang, Yangyang Li, Rui Liang, Dan Li, Bin Li
Immune cell metabolism in tumor microenvironment / Yongsheng Li, Yisong Y. Wan, Bo Zhu
Regulation of metabolism across different subsets of t cells in cancer / Xuerui Luo, Fuxiang Zhu, Zuojia Chen, Dan Li, Bin Li
Innate and adaptive immune cell metabolism in tumor microenvironment / Duojiao Wu.
