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000799753 019__ $$a1003192600$$a1003306262
000799753 020__ $$a9789402411706$$q(electronic book)
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000799753 24500 $$aImmune metabolism in health and tumor /$$cBin Li, Fan Pan, editors.
000799753 264_1 $$aDordrecht, The Netherlands :$$bSpringer,$$c[2017]
000799753 264_4 $$c©2017
000799753 300__ $$a1online resource (v, 223 pages) :$$billustrations.
000799753 336__ $$atext$$btxt$$2rdacontent
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000799753 337__ $$acomputer$$bc$$2rdamedia
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000799753 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vvolume 1011
000799753 504__ $$aIncludes bibliographical references.
000799753 5050_ $$aMetabolism in immune cell differentiation and function / Nicole M. Chapman, Sharad Shrestha, Hongbo Chi -- Metabolic regulation of T cell immunity / Paolo D. A. Vignali, Joseph Barbi, Fan Pan -- Transcriptional regulation of T cell metabolism reprograming / Jinxia Zhang, Guoyu Bi, Yu Xia, Pingfei Li, Xiaofei Deng, Zhengping Wei [and others] -- Adipose tissue-resident regulatory T cells / Fuxiang Zhu, Aiting Wang, Yangyang Li, Rui Liang, Dan Li, Bin Li -- Immune cell metabolism in tumor microenvironment / Yongsheng Li, Yisong Y. Wan, Bo Zhu -- Regulation of metabolism across different subsets of t cells in cancer / Xuerui Luo, Fuxiang Zhu, Zuojia Chen, Dan Li, Bin Li -- Innate and adaptive immune cell metabolism in tumor microenvironment / Duojiao Wu.
000799753 506__ $$aAccess limited to authorized users.
000799753 520__ $$a"This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics"--Publisher's description.
000799753 588__ $$aDescription based on online resource; title from pdf title page (SpringerLink, viewed September 11, 2017).
000799753 650_0 $$aImmune system$$xMetabolism.
000799753 650_0 $$aTumors$$xMetabolism.
000799753 650_0 $$aT cells$$xMetabolism.
000799753 650_0 $$aLeucocytes$$xImmunology.
000799753 7001_ $$aLi, Bin$$c(Immunologist),$$eeditor.
000799753 7001_ $$aPan, Fan$$c(Immuno-oncologist),$$eeditor.
000799753 77608 $$iPrint version:$$tImmune metabolism in health and tumor.$$dDordrecht, the Netherlands : Springer, 2017$$z9402411682$$w(DLC)  2017951122$$w(OCoLC)991689074
000799753 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1011.$$x0065-2598
000799753 852__ $$bebk
000799753 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-94-024-1170-6$$zOnline Access$$91397441.1
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000799753 980__ $$aEBOOK
000799753 980__ $$aBIB
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000799753 983__ $$aOnline
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