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000799811 019__ $$a1003317606$$a1003701844
000799811 020__ $$a9783319601892$$q(electronic book)
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000799811 08204 $$a615.9/253$$223
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000799811 24500 $$aNeurotoxicity of metals /$$cMichael Aschner, Lucio G. Costa, editors.
000799811 260__ $$aCham :$$bSpringer,$$c2017.
000799811 300__ $$a1 online resource.
000799811 336__ $$atext$$btxt$$2rdacontent
000799811 337__ $$acomputer$$bc$$2rdamedia
000799811 338__ $$aonline resource$$bcr$$2rdacarrier
000799811 4901_ $$aAdvances in neurobiology ;$$vv. 18
000799811 5050_ $$aPart I: Developmental Neurotoxicity; Developmental Neurotoxicity of Lead; Introduction; Developmental Exposures to Lead; Neurobehavioral Effects of Lead; Molecular Mechanisms of Neurotoxicity; Developmental Exposures to Lead and Alzheimer's Disease; Conclusions; References; Manganese and Developmental Neurotoxicity; Manganese in the Environment; Airborne Particles; Deposited Dust; Surface Soil; Edible Vegetables; Drinking Water; Toxicology and Biomarkers; Metabolism; Pediatric Absorption; Biomarkers; Effects on Cognitive Functions; Intellectual Ability
000799811 5058_ $$aExecutive Function Memory; Academic Achievement; Effects on Motor Functions; Behavior; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder; Other Behavioral Outcomes; Effects on Olfactory Function; References; Inherited Disorders of Manganese Metabolism; Introduction; SLC30A10; SLC39A14; SLC39A8; Concluding Perspectives; References; Part II: Neurodegenerative Disorders; Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity; Introduction; Selenium in the Environment and in the Living Organisms; Selenium: Neurotoxic or Neuroprotector?
000799811 5058_ $$aFrom Selenide to Selenoproteins Selenoproteins in the Brain; Mercury in the Environment and in the Living Organisms; Inorganic Mercury Neurotoxicity; Organic Mercury Neurotoxicity; Selenium and Mercury: Brain Antagonistic Interactions; Selenium as Antagonist of Inorganic Mercury Neurotoxicity; Selenium as an Antagonist of the Neurotoxicity Induced by Organic Mercury; Conclusion; References; Metals and Paraoxonases; Introduction; PON1; Human Polymorphisms of PON1 and Definition of PON1 Status; Modulation of PON1 Activity and Expression; PON2
000799811 5058_ $$aPON2 as an Intracellular Antioxidant Enzyme Modulation of PON2; PON3: Activity, Polymorphisms, Physiological Functions, and Modulation; Interactions of Metals with PONs; In Vitro Effects of Metals on PONs; Effects of Metals on PONs: Animal Studies; Metals and PONs: Human Studies; Lead; Arsenic; Methylmercury and Selenium; Cadmium; Other Metals; Potential Mechanisms of PON1 Modulation by Metals; Summary and Conclusions; References; Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders; Introduction
000799811 5058_ $$aIIS Signaling and Its Role in the Brain Mn and Insulin/IGF Homeostasis; HD Pathobiology; Mn Dysregulation in HD; IIS Dysregulation in HD; Autophagy Deficits in HD, Potential Links to Mn and IIS; Mitochondrial Pathology in HD, Possible Links to Mn and IIS; IIS Signaling and Mn in Other NDDs; PD and IIS/Mn; AD and IIS/Mn; ALS and IIS/Mn; Autophagy in Other Neurodegenerative Diseases; Manganese Toxicity and IGF; The Co-regulation of ATM, Mn, and Insulin/IGF; IIS Signaling, Mn, and Cancer; Conclusions; References; Occupational Metal Exposure and Parkinsonism; Introduction
000799811 506__ $$aAccess limited to authorized users.
000799811 520__ $$aIn this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.
000799811 588__ $$aDescription based on print version record.
000799811 650_0 $$aMetals$$xToxicology.
000799811 650_0 $$aNeurotoxicology.
000799811 7001_ $$aAschner, Michael$$4edt
000799811 7001_ $$aCosta, Lucio$$4edt
000799811 77608 $$iPrint version:$$z9783319601885$$z3319601881$$w(OCoLC)987282561
000799811 830_0 $$aAdvances in neurobiology ;$$v18.
000799811 852__ $$bebk
000799811 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-60189-2$$zOnline Access$$91397441.1
000799811 909CO $$ooai:library.usi.edu:799811$$pGLOBAL_SET
000799811 980__ $$aEBOOK
000799811 980__ $$aBIB
000799811 982__ $$aEbook
000799811 983__ $$aOnline
000799811 994__ $$a92$$bISE