Dedication; Preface; Contents; About the Editors; Part I: Regulation of Proteases in Health and Disease; 1: Physiological and Pathological Functions of Mitochondrial Proteases; 1.1 Introduction; 1.2 Physiological Roles of Mitoproteases; 1.2.1 Proteolysis in the Outer Membrane; 1.2.2 Proteolysis in the Intermembrane Space; 1.2.3 Proteolysis in the Inner Membrane; 1.2.4 Proteolysis in the Mitochondrial Matrix; 1.3 Pathological Contributions of Mitoproteases; 1.3.1 Mitochondrial Proteases in Cancer; 1.3.2 Mitochondrial Proteases in Neurodegenerative Diseases

1.3.3 Mitochondrial Proteases in Multisystemic Diseases1.4 Conclusions; References; 2: The Role of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Embryonic Neural Crest Cells and Their Derivatives; 2.1 Introduction; 2.2 Matrix Metalloproteinases; 2.3 MMP-2 and MMP-9 in the Onset of NCC Migration; 2.4 MMP-2 and MMP-9 in NCC Derivatives in Embryos and Adults; 2.4.1 Cranial Cartilage and Bone; 2.4.2 Heart; 2.4.3 Melanocytes; 2.4.4 Adipocytes; 2.4.5 Enteric Neurons; 2.4.6 Glial Cells; 2.5 Activators and Repressors of MMP-2 and MMP-9 in NCCs; 2.6 Conclusion; References

3: The Matrix Metalloproteinase and Tissue Inhibitors of Metalloproteinase Balance in Physiological and Pathological Remodeling of Skeletal Muscles3.1 Introduction; 3.2 MMPs and TIMPs in Skeletal Muscles: Expression and Role; 3.2.1 MMPs /TIMPs in Skeletal Muscle Cells; 3.2.1.1 Role of MMPs in Myogenic Cells; MMPs Contribute to Cell Migration; MMPs Contribute to Cell Fusion; 3.3 MMPs in Remodeling Skeletal Muscles; 3.3.1 Skeletal Muscle Plasticity; 3.3.2 Skeletal Muscle Degeneration and Regeneration; 3.4 Deregulation of MMPs in Skeletal Muscle Diseases; 3.4.1 Inflammatory Myopathies

3.4.2 Muscular Dystrophies3.4.3 Neurogenic Myopathies; 3.5 MMPs/TIMPs Are Involved in Inflammation and Fibrosis of Diseased Skeletal Muscles; 3.5.1 MMP Involvement in Skeletal Muscle Inflammation; 3.5.2 MMP/TIMP Involvement in Skeletal Muscle Fibrosis; 3.6 Conclusion and Perspectives; References; 4: Role of BMP1/Tolloid like Proteases in Bone Morphogenesis and Tissue Remodeling; 4.1 Introduction; 4.2 Structure of the Protease Domain of BTPs; 4.2.1 Primary Structure; 4.2.2 X-ray Structure; 4.3 Substrate Specificity; 4.4 Biological Roles of BTPs; 4.4.1 Matrix Assembly

4.4.2 Activation of Signalling Molecules4.5 BTP's and Disease; 4.5.1 Fibrosis; 4.5.2 Bone Disorders; 4.5.3 Cancer; 4.6 Modulators of BTPs; 4.6.1 Activators; 4.6.2 Inhibitors; 4.7 Conclusion and Future Perspectives; References; 5: Role of Proteases in the Regulation of N-Myristoyltransferase; 5.1 Introduction; 5.2 Differential Regulation of N-Myristoyltransferase Isoforms; 5.3 Regulation of NMT Functions by Proteases; 5.4 Summary; References; 6: Role of Tissue Factor-FVIIa Blood Coagulation Initiation Complex in Cancer; 6.1 Introduction