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Table of Contents
Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders
1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks
2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action
5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases
Part II. PDEs in Cognition of Aging and Alzheimer's Disease
6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases
7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss
8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
9. Role of PDE9 in Cognition
Part III. PDEs in Parkinson's and Huntington's Diseases
10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease
11. Role of Phosphodiesterases in Huntington's Disease
Part IV. PDEs and Psychiatric Disorders
12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
14. PDE Inhibitors for the Treatment of Schizophrenia
Part V. PDEs and Others
15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors
17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.
1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks
2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action
5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases
Part II. PDEs in Cognition of Aging and Alzheimer's Disease
6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases
7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss
8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
9. Role of PDE9 in Cognition
Part III. PDEs in Parkinson's and Huntington's Diseases
10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease
11. Role of Phosphodiesterases in Huntington's Disease
Part IV. PDEs and Psychiatric Disorders
12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
14. PDE Inhibitors for the Treatment of Schizophrenia
Part V. PDEs and Others
15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors
17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.