Introduction
Overview of the contemporary literature
Pessimistic, optimistic and pragmatic approaches to interdisciplinarity
Core concepts of critical realism
Critical realism and social science
The ontological case for interdisciplinarity
The seven steps to a deeper understanding of ontology
Critical realism and the alternative metatheories/methodologies
Biophysical interventions are not enough
The seven enigmas of healing
The biopsychosocial approach and the ICF
The practical organization of interdisciplinary co-operation
Understanding methodological imperialism
Interdisciplinarity in action: explaining the epidemiology of HIV
Concluding considerations.