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Foreword; Preface to the Second Edition; Acknowledgment; Contents; 1: Basic Sciences of Bone and Joint Diseases; 1.1 Introduction; 1.2 Anatomy and Physiology of Bone; 1.2.1 Bone Development; 1.2.2 Bone Anatomy; 1.2.2.1 General Structural Features; 1.2.2.2 Blood Supply of Bone; 1.2.2.3 Features of Individual Bones; 1.2.3 Bone Physiology; 1.2.3.1 Bone Function; 1.2.3.2 Bone Metabolism; 1.3 Anatomy and Physiology of Bone Marrow; 1.4 Anatomy and Physiology of Joints; 1.5 Spectrum of Bone and Joint Disease; 1.6 Modalities for Imaging Bone and Joint Diseases
1.7 Diagnosis of Bone and Joint Diseases by Nuclear Medicine Techniques1.8 Technical Considerations; 1.8.1 Pre-imaging Considerations; 1.8.1.1 Bone Imaging Radiopharmaceuticals; 1.8.1.2 Patient Preparation; 1.8.1.3 Patient History and Examination; 1.8.1.4 Time of Imaging After Injection; 1.8.2 Imaging Considerations; 1.8.2.1 Instrumentation; 1.8.2.2 Positioning; 1.8.2.3 Acquisition; 1.8.3 Post-Imaging Considerations; 1.8.4 Sources of Diagnostic Errors; References; 2: Diagnosis of Inflammatory Bone Diseases; 2.1 Introduction; 2.2 Pathophysiology; 2.2.1 Inflammation
2.2.1.1 Definition2.2.1.2 Classification; 2.2.1.3 General Pathophysiological Features; 2.2.1.4 Healing; 2.2.1.5 Inflammation in Cancer Patients; 2.2.2 Skeletal Infections; 2.2.2.1 Definitions; 2.2.2.2 Classification; 2.2.2.3 General Pathophysiological Features; 2.2.2.4 Features of Specific Forms; 2.3 Imaging Skeletal Infections; 2.3.1 The Need for Diagnostic Imaging; 2.3.2 Imaging Modalities for Skeletal Infections; 2.4 Diagnosis of Skeletal Infection by Imaging; 2.4.1 Diagnosis Using Morphologic Imaging Modalities; 2.4.1.1 Standard Radiographs; 2.4.1.2 Ultrasonography
2.4.1.3 Computed Tomography2.4.1.4 Magnetic Resonance Imaging; 2.4.2 Diagnosis by Scintigraphic Methods; 2.4.2.1 Radiopharmaceuticals for Infection Imaging; 2.4.2.2 Bone Scanning; 2.4.2.3 Gallium-67 Citrate Imaging; 2.4.2.4 Labeled Leukocyte Imaging; 2.4.2.5 Immunoscintigraphy; 2.4.2.6 Positron Emission Tomography Imaging; 2.4.3 Imaging Using Combined Modalities; 2.5 Diagnosis of Specific Forms of Skeletal Infections; 2.5.1 Diabetic Foot Osteomyelitis; 2.5.2 Vertebral Osteomyelitis (Spondylodiscitis); 2.5.3 Chronic Active Osteomyelitis; 2.5.4 Periprosthetic Infection
2.5.5 Posttraumatic Osteomyelitis2.5.6 Osteomyelitis in Patients with Sickle Cell Disease; 2.5.7 Neonatal Osteomyelitis; 2.5.8 Epiphyseal Osteomyelitis; 2.6 Follow-Up of Response to Therapy; 2.7 Differentiating Osteomyelitis from Infectious Arthritis; 2.8 Differentiating Infection from Tumors; 2.9 Noninfectious Inflammatory Conditions; 2.9.1 Chronic Nonbacterial Osteomyelitis; 2.9.1.1 Chronic Recurrent Multifocal Osteomyelitis; 2.9.1.2 Chronic Sclerosing Osteomyelitis; 2.9.2 Osteitis Condensans Ilii; 2.9.3 Osteitis Pubis
1.7 Diagnosis of Bone and Joint Diseases by Nuclear Medicine Techniques1.8 Technical Considerations; 1.8.1 Pre-imaging Considerations; 1.8.1.1 Bone Imaging Radiopharmaceuticals; 1.8.1.2 Patient Preparation; 1.8.1.3 Patient History and Examination; 1.8.1.4 Time of Imaging After Injection; 1.8.2 Imaging Considerations; 1.8.2.1 Instrumentation; 1.8.2.2 Positioning; 1.8.2.3 Acquisition; 1.8.3 Post-Imaging Considerations; 1.8.4 Sources of Diagnostic Errors; References; 2: Diagnosis of Inflammatory Bone Diseases; 2.1 Introduction; 2.2 Pathophysiology; 2.2.1 Inflammation
2.2.1.1 Definition2.2.1.2 Classification; 2.2.1.3 General Pathophysiological Features; 2.2.1.4 Healing; 2.2.1.5 Inflammation in Cancer Patients; 2.2.2 Skeletal Infections; 2.2.2.1 Definitions; 2.2.2.2 Classification; 2.2.2.3 General Pathophysiological Features; 2.2.2.4 Features of Specific Forms; 2.3 Imaging Skeletal Infections; 2.3.1 The Need for Diagnostic Imaging; 2.3.2 Imaging Modalities for Skeletal Infections; 2.4 Diagnosis of Skeletal Infection by Imaging; 2.4.1 Diagnosis Using Morphologic Imaging Modalities; 2.4.1.1 Standard Radiographs; 2.4.1.2 Ultrasonography
2.4.1.3 Computed Tomography2.4.1.4 Magnetic Resonance Imaging; 2.4.2 Diagnosis by Scintigraphic Methods; 2.4.2.1 Radiopharmaceuticals for Infection Imaging; 2.4.2.2 Bone Scanning; 2.4.2.3 Gallium-67 Citrate Imaging; 2.4.2.4 Labeled Leukocyte Imaging; 2.4.2.5 Immunoscintigraphy; 2.4.2.6 Positron Emission Tomography Imaging; 2.4.3 Imaging Using Combined Modalities; 2.5 Diagnosis of Specific Forms of Skeletal Infections; 2.5.1 Diabetic Foot Osteomyelitis; 2.5.2 Vertebral Osteomyelitis (Spondylodiscitis); 2.5.3 Chronic Active Osteomyelitis; 2.5.4 Periprosthetic Infection
2.5.5 Posttraumatic Osteomyelitis2.5.6 Osteomyelitis in Patients with Sickle Cell Disease; 2.5.7 Neonatal Osteomyelitis; 2.5.8 Epiphyseal Osteomyelitis; 2.6 Follow-Up of Response to Therapy; 2.7 Differentiating Osteomyelitis from Infectious Arthritis; 2.8 Differentiating Infection from Tumors; 2.9 Noninfectious Inflammatory Conditions; 2.9.1 Chronic Nonbacterial Osteomyelitis; 2.9.1.1 Chronic Recurrent Multifocal Osteomyelitis; 2.9.1.2 Chronic Sclerosing Osteomyelitis; 2.9.2 Osteitis Condensans Ilii; 2.9.3 Osteitis Pubis