Sigma proteins : evolution of the concept of sigma receptors / Felix J. Kim, Gavril W. Pasternak, editors.
Kim, Felix J., editor.; Pasternak, Gavril W., editor.
2017
RM301.41
Available Online

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Title Sigma proteins : evolution of the concept of sigma receptors / Felix J. Kim, Gavril W. Pasternak, editors.
ISBN 9783319658537 (electronic book)
3319658530 (electronic book)
9783319658513
3319658514
Published Cham, Switzerland : Springer, [2017]
Copyright ©2017
Language English
Description 1 online resource (viii, 330 pages) : illustrations.
Call Number RM301.41
Dewey Decimal Classification 615.1/9
Summary "Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives"--Publisher's description.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from electronic title page (SpringerLink, viewed November 2, 2017).
Added Author Kim, Felix J., editor.
Pasternak, Gavril W., editor.
Series Handbook of experimental pharmacology ; v. 244. 0171-2004
Available in Other Form Sigma proteins.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Introduction to sigma proteins: evolution of the concept of sigma receptors / Felix J. Kim
Structural insights into sigma1 function / Andrew Kruse
3d homology model of sigma1 receptor / Erik Laurini, Domenico Marson, Maurizio Fermeglia, Sabrina Pricl
Medicinal chemistry of [sigma]1 receptor ligands: pharmacophore models, synthesis, structure affinity relationships, and pharmacological applications / Frauke Weber, Bernhard Wünsch
Sigma-1 ([sigma]1) receptor in memory and neurodegenerative diseases / Tangui Maurice, Nino Goguadze
Sigma-1 receptor and neuronal excitability / Saïd Kourrich
Sigma-1 receptor and pain / Manuel Merlos, Luz Romero, Daniel Zamanillo, Carlos Plata-Salamán, José Miguel Vela
Allosteric modulation of opioid g-protein coupled receptors by sigma1 receptors / Gavril W. Pasternak
A role for sigma receptors in stimulant self-administration and addiction / Jonathan L. Katz, Takato Hiranita, Weimin C. Hong, Martin O. Job, Christopher R. McCurdy
Sigma receptors and alcohol use disorders / Valentina Sabino, Pietro Cottone
Sigma1 pharmacology in the context of cancer / Felix J. Kim, Christina M. Maher
Molecular probes for imaging the sigma-2 receptor: in vitro and in vivo imaging studies / Chenbo Zeng, Elizabeth S. McDonald, Robert H. Mach.

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