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000807200 24500 $$aCellular therapies for retinal disease :$$ba strategic approach /$$cSteven D. Schwartz, Aaron Nagiel, Robert Lanza, editors ; foreword by Mark S. Blumenkranz.
000807200 264_1 $$aCham :$$bSpringer,$$c[2017]
000807200 264_4 $$c©2017
000807200 300__ $$a1 online resource (xiii, 143 pages)
000807200 336__ $$atext$$btxt$$2rdacontent
000807200 337__ $$acomputer$$bc$$2rdamedia
000807200 338__ $$aonline resource$$bcr$$2rdacarrier
000807200 347__ $$atext file$$bPDF$$2rda
000807200 504__ $$aIncludes bibliographical references and index.
000807200 5050_ $$aPart I- Cell Replacement Therapy -- 1. Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cell Transplantation for Retinal Degeneration -- 2. Stem Cell-Derived RPE transplantation: the feasibility and advantages of delivery as monolayers -- 3. Induced Pluripotent Stem Cell-Derived Autologous Cell Therapy for Age-related Macular Degeneration -- 4. Scaffolds for Cell Transplantation -- 5. Surgical Approaches for Cell Transplantation in Cell Replacement Therapy -- 6. Cell Transplantation Therapy for Glaucoma. Part II -- Cell-based Neuroprotection -- 7. Autologous Bone Marrow-Derived Cell Therapies for Retinal Disease -- 8. Subretinal Delivery of Cells Via the Suprachoroidal Space: The Janssen Trial. Part III -- Disease Modeling using Induced Pluripotent Stem Cells -- 9. "Disease in a Dish" Modeling of Retinal Diseases -- 10. Retinal Organoids: An Emerging Technology for Retinal Disease Research and Therapy.
000807200 506__ $$aAccess limited to authorized users.
000807200 520__ $$aThis book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book--edited by world-renowned stem cell scientists--focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph. D. level.
000807200 588__ $$aVendor-supplied metadata.
000807200 650_0 $$aRetina$$xDiseases.
000807200 650_0 $$aRetina$$xDiseases$$xTreatment.
000807200 650_0 $$aCellular therapy.
000807200 7001_ $$aSchwartz, Steven D.,$$eeditor.
000807200 7001_ $$aNagiel, Aaron,$$eeditor.
000807200 7001_ $$aLanza, Robert,$$eeditor.
000807200 77608 $$iPrint version:$$tCellular therapies for retinal disease.$$dCham : Springer, [2017]$$z3319494775$$z9783319494777$$w(OCoLC)961001770
000807200 852__ $$bebk
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