@article{807361,
      recid = {807361},
      author = {Yoshimura, Akihiko.},
      title = {Emerging concepts targeting immune checkpoints in cancer  and autoimmunity /},
      pages = {1 online resource (268 pages)},
      abstract = {This volume reviews the current state of research on  immune checkpoints and offers novel concepts. It discusses  the two most important immune checkpoints: T  lymphocyte-associated antigen-4 (CTLA-4) and programmed  cell death-1 (PD-1). It shows that antagonistic antibodies  against these two molecules are highly effective in the  treatment of various cancers and that PD-1 and CTLA-4 have  been linked to the suppression of T-cell receptor signaling  and co-stimulatory molecules. Further, the volume examines  other agents, a number of cells, receptors and signaling  molecules, that are also involved in the regulation of  T-cell activation and extends the concept of immune  checkpoints to “molecules and cells that negatively  regulate T-cell activation”. Playing essential roles in  immune homeostasis, they could offer new targets for cancer  immunotherapy, and for the therapy of autoimmune diseases.  Written by internationally respected scientists, this book  will appeal to basic scientists, clinicians, drug  development researchers, and advanced students alike.},
      url = {http://library.usi.edu/record/807361},
}