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000807361 019__ $$a1013592696$$a1013884682
000807361 020__ $$a9783319689296$$q(electronic book)
000807361 020__ $$a3319689290$$q(electronic book)
000807361 020__ $$z9783319689289
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000807361 24500 $$aEmerging concepts targeting immune checkpoints in cancer and autoimmunity /$$cAkihiko Yoshimura, editor.
000807361 264_1 $$aCham :$$bSpringer,$$c2017.
000807361 300__ $$a1 online resource (268 pages)
000807361 336__ $$atext$$btxt$$2rdacontent
000807361 337__ $$acomputer$$bc$$2rdamedia
000807361 338__ $$aonline resource$$bcr$$2rdacarrier
000807361 4901_ $$aCurrent Topics in Microbiology and Immunology ;$$vv.410
000807361 5050_ $$aRegulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation.
000807361 506__ $$aAccess limited to authorized users.
000807361 520__ $$aThis volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
000807361 588__ $$aDescription based on print version record.
000807361 650_0 $$aImmune response$$xRegulation.
000807361 650_0 $$aCancer$$xImmunological aspects.
000807361 7001_ $$aYoshimura, Akihiko.
000807361 77608 $$iPrint version:$$aYoshimura, Akihiko$$tEmerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity$$dCham : Springer International Publishing AG, z.Hd. Alexander Grossmann,c2017$$z9783319689289
000807361 830_0 $$aCurrent topics in microbiology and immunology ;$$v410.
000807361 852__ $$bebk
000807361 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-68929-6$$zOnline Access$$91397441.1
000807361 909CO $$ooai:library.usi.edu:807361$$pGLOBAL_SET
000807361 980__ $$aEBOOK
000807361 980__ $$aBIB
000807361 982__ $$aEbook
000807361 983__ $$aOnline
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