000812449 000__ 04012cam\a2200481Ki\4500 000812449 001__ 812449 000812449 005__ 20210515142534.0 000812449 006__ m\\\\\o\\d\\\\\\\\ 000812449 007__ cr\cn\nnnunnun 000812449 008__ 180426s2016\\\\maua\\\\ob\\\\001\0\eng\d 000812449 019__ $$a961933973$$a980620268$$a1005112732$$a1005326093$$a1007388634 000812449 020__ $$a9780674969582$$q(electronic book) 000812449 020__ $$a0674969588$$q(electronic book) 000812449 020__ $$z9780674088740 000812449 020__ $$z0674088743 000812449 035__ $$a(OCoLC)ocn953735250 000812449 035__ $$a(OCoLC)953735250$$z(OCoLC)961933973$$z(OCoLC)980620268$$z(OCoLC)1005112732$$z(OCoLC)1005326093$$z(OCoLC)1007388634 000812449 035__ $$a812449 000812449 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dYDXCP$$dYDX$$dOCLCO$$dNJR$$dOCLCA$$dOCLCQ$$dOCLCO 000812449 049__ $$aISEA 000812449 050_4 $$aRC269.7$$b.L37 2016eb 000812449 08204 $$a616.99/407$$223 000812449 1001_ $$aLaplane, Lucie,$$d1984-$$eauthor. 000812449 24510 $$aCancer stem cells :$$bphilosophy and therapies /$$cLucie Laplane. 000812449 264_1 $$aCambridge, Massachusetts :$$bHarvard University Press,$$c2016. 000812449 300__ $$a1 online resource (x, 252 pages) :$$billustrations 000812449 336__ $$atext$$btxt$$2rdacontent 000812449 337__ $$acomputer$$bc$$2rdamedia 000812449 338__ $$aonline resource$$bcr$$2rdacarrier 000812449 504__ $$aIncludes bibliographical references and index. 000812449 5050_ $$aPart I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? 000812449 506__ $$aAccess limited to authorized users. 000812449 520__ $$a"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher. 000812449 588__ $$aDescription based on print version record. 000812449 650_0 $$aCancer cells. 000812449 650_0 $$aStem cells. 000812449 650_0 $$aCancer$$xTreatment$$xPhilosophy. 000812449 650_0 $$aOncology. 000812449 77608 $$iPrint version:$$aLaplane, Lucie, 1984-$$tCancer stem cells.$$dCambridge, Massachusetts : Harvard University Press, 2016$$z9780674088740$$w(DLC) 2015042054$$w(OCoLC)926061404 000812449 852__ $$bacq 000812449 85280 $$bebk$$hEBSCOhost 000812449 85640 $$3eBooks on EBSCOhost$$uhttps://univsouthin.idm.oclc.org/login?url=http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1287333$$zOnline Access 000812449 909CO $$ooai:library.usi.edu:812449$$pGLOBAL_SET 000812449 980__ $$aEBOOK 000812449 980__ $$aBIB 000812449 982__ $$aEbook 000812449 983__ $$aOnline 000812449 994__ $$a92$$bISE