Preface; Contents; Part I Biological Systems; Multiscale Aspects in the Multiphasic Modelling of Human Brain Tissue ; 1 Introduction and Motivation; 2 Anatomic Elements of Human Brain Tissue; 3 TPM Model of the Overall Brain-Tissue Aggregate; 4 Microscopically Underlaid Macroscopic Constitutive Relation; 4.1 Microscopic Model Settings; 4.2 Macroscopic Constitutive Relation; 4.3 Results and Discussion; References; Simulation of Steatosis Zonation in Liver Lobule
A Continuummechanical Bi-Scale, Tri-Phasic, Multi-Component Approach; 1 Introduction; 2 Glucose and Fat Metabolism

3 Numerical Example: Comparison of Different Assumptions for the Perfusion Coupled to the Metabolism3.1 Discussion; References; 3 Nano-Mechanical Tensile Behavior of the SPTA1 Gene in the Presence of Hereditary Hemolytic Anemia-Related Point Mutations; Abstract; 1 Introduction; 2 Spectrin Structure; 3 Materials and Methods; 4 Results; 5 Discussion; Acknowledgements; References; The Choice of a Performance Indicator of Release in Transdermal Drug Delivery Systems ; 1 Introduction; 2 The Concept of an Effective Time Constant: Definition and Applications; 3 A One-Layer Model for TDD

4 Computation of the ETC for a One-Layer Skin Model5 A Multi-layer Model for TDD; 6 Computation of the ETC for a Multi-layer Skin Model; 7 Computational Results; 8 Conclusions; References; Part II Cardiovascular Medicine; 5 Multiscale Multiphysic Approaches in Vascular Hemodynamics; Abstract; 1 Introduction; 2 Geometry Creation and General Simulation Settings; 3 Boundary Conditions; 3.1 Lumped Parameter Modeling; 3.2 0-D/3-D Coupling; 4 Fluid-Structure-Interaction; 4.1 0-D/3-D Coupling of FSI Simulations; 5 Examples; 5.1 An FSI Model of Cardiopulmonary Bypass with Cerebral Autoregulation

5.2 A CFD Model of VAD Support Using Closed-Loop Multiscale Simulations to Evaluate Various Cannulation Strategies5.3 A Numerical Framework to Investigate Hemodynamics During Endovascular Mechanical Recanalization in Acute Stroke; 6 Conclusion; References; Heart Valve Flow Computation with the Space
Time Slip Interface Topology Change (ST-SI-TC) Method and Isogeometric Analysis (IGA); 1 Introduction; 2 ST-VMS and ST-SI Formulations; 2.1 ST-VMS Formulation; 2.2 ST-SI Formulation; 3 ST-SI-TC-IGA Method; 3.1 ST-SI Method; 3.2 ST-TC Method; 3.3 ST-IGA Method

3.4 Integration of the ST-SI, ST-TC and ST-IGA Methods4 Aortic-Valve Model; 4.1 Geometry; 4.2 Mesh and Flow Conditions; 4.3 Computational Conditions; 4.4 Results; 5 Concluding Remarks; References; Estimation of Element-Based Zero-Stress State in Arterial FSI Computations with Isogeometric Wall Discretization ; 1 Introduction; 2 Element-Based Total Lagrangian (EBTL) Method; 2.1 EBZSS; 2.2 NURBS Basis Functions; 2.3 EBZSS Representation with NURBS Basis Functions; 3 Modeling the Artery ZSS: Straight-Tube ZSS Template; 4 2D Test Computations; 4.1 Meshes; 4.2 Curvature Matching in the ZSS