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Foreword
Preface
1 Anatomophysiology of the neuroendocrine system: Embryology, Anatomy
Histology
Citology, Physiology
2 Epidemiology: Risk factors
3 Classification: WHO (grading), site
4 Pathology: Anatomic pathology, Immunohistochemistry.
5 Molecular biology: Molecular pathways, Oncogenes, Suppressor genes
6 Clinical presentations: Non functioning NETs
7 Clinical presentations: Hormone releasing NETs (Carcinoid syndrome, Insulinoma, Glucagonoma, VIPoma, Somatostatinoma, Others, GRFoma
8 MEN 1, MEN 2am, MEN 2b, and Others (TSC, VHL, NF1)
9 Diagnosis: (Serum biomarkers, Endoscopy, Imaging (US, CT Scan, MRI, Angiography, Scintigraphy, PET)
10 Staging: TNM
11 Surgical treatment: Gastric NETs, Duodenum NETs, Jejuno-ileal NETs, Colorectal NETs, Pancreatic NETs (Head, Body-tail), Adrenal NETs
12 Non surgical treatments: Chemotherapy, Hormonal syndrome treatment, Targeted therapies, IFN
13 Metastatic disease: Liver metastases (Surgery, RF ablation and cryoablation, Arterial chemoembolization)
14 Systemic therapy (Somatostatina analogs, Alpha IFN, Cytotoxic chemotherapy, Peptide receptor radiotherapy, VEGF inhibitors, mTOR inhibitors
15 Flow-charts.

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