000825648 000__ 05426cam\a2200541Ii\4500
000825648 001__ 825648
000825648 005__ 20230306144227.0
000825648 006__ m\\\\\o\\d\\\\\\\\
000825648 007__ cr\cn\nnnunnun
000825648 008__ 180111s2018\\\\sz\\\\\\o\\\\\001\0\eng\d
000825648 019__ $$a1019602243$$a1021194381$$a1027045898
000825648 020__ $$a9783319680828$$q(electronic book)
000825648 020__ $$a331968082X$$q(electronic book)
000825648 020__ $$z9783319680804
000825648 020__ $$z3319680803
000825648 0247_ $$a10.1007/978-3-319-68082-8$$2doi
000825648 035__ $$aSP(OCoLC)on1018942593
000825648 035__ $$aSP(OCoLC)1018942593$$z(OCoLC)1019602243$$z(OCoLC)1021194381$$z(OCoLC)1027045898
000825648 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dEBLCP$$dGW5XE$$dAZU$$dUAB$$dUPM$$dMERER$$dOCLCQ$$dYDX
000825648 049__ $$aISEA
000825648 050_4 $$aRC280.L5
000825648 08204 $$a616.99/43607$$223
000825648 24500 $$aPrecision molecular pathology of liver cancer /$$cChen Liu, editor.
000825648 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000825648 300__ $$a1 online resource.
000825648 336__ $$atext$$btxt$$2rdacontent
000825648 337__ $$acomputer$$bc$$2rdamedia
000825648 338__ $$aonline resource$$bcr$$2rdacarrier
000825648 347__ $$atext file$$bPDF$$2rda
000825648 4901_ $$aMolecular pathology library
000825648 500__ $$aIncludes index.
000825648 5050_ $$aIntro; Preface; Contents; Contributors; 1: Etiology and Pathogenesis of Hepatocellular Carcinoma; 1.1 Introduction; 1.2 Etiology; 1.3 Virus-Induced Hepatocarcinogenesis; 1.3.1 HBV; 1.3.2 HCV; 1.4 NAFLD Cirrhosis-Induced Hepatocarcinogenesis; 1.5 Toxin-Mediated Hepatocarcinogenesis; 1.5.1 Alcohol Induced; 1.5.2 Aflatoxin-B1 Induced; 1.6 Common Themes; 1.7 Molecular Mechanisms; 1.7.1 Methylation; 1.7.2 MET and HGF; 1.7.3 ErbB Receptor Family; 1.7.4 B-Catenin; 1.7.5 p53 Tumor Suppression; References.
000825648 5058_ $$a2: Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications2.1 Conventional Hepatocellular Carcinoma (HCC); 2.2 Small HCC; 2.3 Special Histologic Subtypes; 2.3.1 Fibrolamellar HCC; 2.3.2 Scirrhous HCC; 2.3.3 Steatohepatitic HCC; 2.3.4 Lymphoepithelioma-Like HCC (LEL-HCC); 2.3.5 Sarcomatoid HCC; 2.3.6 Undifferentiated Carcinoma; 2.3.7 Diffuse Cirrhosis-Like HCC (CL-HCC); 2.3.8 Combined Hepatocellular-Cholangiocarcinoma; 2.4 Grading and Staging; 2.4.1 Grading HCC; 2.4.2 Staging HCC; References.
000825648 5058_ $$a3: Molecular Classification of Hepatocellular Carcinoma and Precision Medicine3.1 Introduction; 3.2 Molecular Alterations; 3.2.1 TERT; 3.2.2 Wnt/β-Catenin; 3.2.3 p53; 3.2.4 CDKN2A (p16); 3.2.5 AXIN1 and 2; 3.2.6 RAS; 3.2.7 MET; 3.2.8 TGFβ; 3.2.9 VEGFA; 3.2.10 EpCAM; 3.2.11 PTEN; 3.2.12 Epigenetic Alterations; 3.2.13 Chromosome Instability; 3.3 Molecular Classification; 3.3.1 Overview; 3.3.2 Proliferation Class; 3.3.3 Nonproliferation Class; References; 4: Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing.
000825648 5058_ $$a4.1 Hepatocellular Carcinoma and Its Heterogeneity4.1.1 HCC Heterogeneity in Etiology; 4.1.2 HCC Heterogeneity in Clinical Presentation; 4.1.3 HCC Heterogeneity at the Biological Level; 4.2 Next-Generation Sequencing System; 4.2.1 Roche 454 Sequencing; 4.2.2 Illumina Sequencing; 4.2.3 SOLiD Sequencing; 4.2.4 Ion Personal Genome Machine; 4.2.5 The Third-Generation Sequencers; 4.3 HCC Genomics Studies via NGS Technology; 4.3.1 HCC Viral Risk Factors in Viral-Related HCCs; HBV Integration in HBV-Related HCCs; HCV Quasispecies Diversity in Chronic Liver Disease and HCC.
000825648 5058_ $$a4.3.2 Mutational Landscapes in HCCWNT/Beta-Catenin Pathway and P53 Pathway; Chromatin Regulators; PI3K/Akt/mTOR-Pathway and MAPK Pathway; Others; 4.3.3 Expression Profiles of HCC; 4.3.4 Epigenetic Alterations in HCC; 4.3.5 Potential Clinical Utilization in HCC; 4.4 Conclusion and Prospective; References; 5: Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application; 5.1 Introduction; 5.2 Epigenetics; 5.2.1 DNA Methylation; 5.2.2 Micro RNAs; 5.2.3 Histone Modifications and Histone Variants; 5.3 Hepatitis B Virus-Associated Hepatocellular Carcinoma.
000825648 506__ $$aAccess limited to authorized users.
000825648 520__ $$aThis volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.#xE003.
000825648 588__ $$aOnline resource; title from PDF title page (viewed January 15, 2018).
000825648 650_0 $$aLiver$$xCancer$$xMolecular aspects.
000825648 650_0 $$aLiver$$xCancer$$xDiagnosis.
000825648 7001_ $$aLiu, Chen,$$eeditor.
000825648 77608 $$iPrint version: $$z9783319680804
000825648 830_0 $$aMolecular pathology library series.
000825648 852__ $$bebk
000825648 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-68082-8$$zOnline Access$$91397441.1
000825648 909CO $$ooai:library.usi.edu:825648$$pGLOBAL_SET
000825648 980__ $$aEBOOK
000825648 980__ $$aBIB
000825648 982__ $$aEbook
000825648 983__ $$aOnline
000825648 994__ $$a92$$bISE