Linked e-resources
Details
Table of Contents
Intro; Preface; Contents; Chapter 1: Overview: In Silico Approaches to Understand Bone Adaptation; 1.1 Introduction; 1.2 Modeling Bone Adaptation from Cellular to Tissue Level; 1.3 Modeling Bone Adaptation from Tissue to Organ Level; 1.4 Open Questions and Future Directions; 1.4.1 Osteocyte Mechanotransduction; 1.4.2 Osteocyte Morphology; 1.4.3 Signaling in Bone Metabolism; 1.5 Conclusion; References; Chapter 2: Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus; 2.1 Introduction; 2.2 Three-Dimensional Reconstruction of Osteocytes in Canaliculi; 2.3 Computational Fluid Flow Analysis.
2.4 Model of Osteocyte Canaliculi2.5 Interstitial Fluid Flow in Osteocyte Canaliculi; 2.6 Importance of Canalicular Microstructure in Osteocyte Mechanosensing; 2.7 Conclusion; References; Chapter 3: Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula; 3.1 Introduction; 3.2 Theory of Poroelasticity; 3.2.1 Constitutive Relations; 3.2.2 Governing Equations; 3.3 Poroelastic Modeling of a Single Trabecula; 3.3.1 Formulation of Poroelastic Problem; 3.3.2 Analytical Solution for Fluid Pressure; 3.4 Interstitial Fluid Pressure in Trabecula; 3.4.1 Description of Fluid Pressure Behavior.
3.4.2 Steady-State Response3.4.3 Transient Response; 3.5 Importance of Transient Fluid Pressure Response; 3.6 Implications of Fluid Flow in Trabecular Bone Remodeling; 3.7 Conclusion; References; Chapter 4: Estimation of Bone Permeability for Poroelastic Analysis; 4.1 Introduction; 4.2 Confocal Laser Scanning Imaging of Lacuno-Canalicular Porosity; 4.3 Theoretical Method for Estimating Bone Permeability; 4.3.1 Quantification of Canalicular Anisotropy; 4.3.2 Estimation of Trabecular Bone Permeability; 4.4 Application to Confocal Laser Scanning Imaging.
4.4.1 Quantification of Canalicular Anisotropy4.4.2 Estimation of Trabecular Bone Permeability; 4.5 Validation of the Estimated Bone Permeability; 4.6 Characteristics of the Proposed Estimation Method; 4.7 Conclusion; References; Chapter 5: Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes; 5.1 Introduction; 5.2 Mathematical Model of Trabecular Bone Remodeling; 5.2.1 Theoretical Framework; 5.2.2 Cellular Mechanosensing; 5.2.3 Intercellular Signal Transmission; 5.2.4 Trabecular Surface Movement; 5.3 Voxel Modeling of a Single Trabecula under Cyclic Uniaxial Load.
5.4 Adaptation of a Single Trabecula to Cyclic Uniaxial Load5.4.1 Morphological Changes in Trabecula; 5.4.2 Quantitative Evaluation of Remodeling Process; 5.5 Characteristics of the Proposed Remodeling Model; 5.6 Validity of the Simulated Remodeling Process; 5.7 Conclusion; References; Chapter 6: Effects of Local Bending Load on Trabecular Bone Adaptation; 6.1 Introduction; 6.2 Voxel Modeling of a Single Trabecula under a Cyclic Bending Load; 6.3 Adaptation of a Single Trabecula to a Cyclic Bending Load; 6.4 Role of Local Bending Load in Bone Remodeling; 6.5 Conclusion; References.
2.4 Model of Osteocyte Canaliculi2.5 Interstitial Fluid Flow in Osteocyte Canaliculi; 2.6 Importance of Canalicular Microstructure in Osteocyte Mechanosensing; 2.7 Conclusion; References; Chapter 3: Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula; 3.1 Introduction; 3.2 Theory of Poroelasticity; 3.2.1 Constitutive Relations; 3.2.2 Governing Equations; 3.3 Poroelastic Modeling of a Single Trabecula; 3.3.1 Formulation of Poroelastic Problem; 3.3.2 Analytical Solution for Fluid Pressure; 3.4 Interstitial Fluid Pressure in Trabecula; 3.4.1 Description of Fluid Pressure Behavior.
3.4.2 Steady-State Response3.4.3 Transient Response; 3.5 Importance of Transient Fluid Pressure Response; 3.6 Implications of Fluid Flow in Trabecular Bone Remodeling; 3.7 Conclusion; References; Chapter 4: Estimation of Bone Permeability for Poroelastic Analysis; 4.1 Introduction; 4.2 Confocal Laser Scanning Imaging of Lacuno-Canalicular Porosity; 4.3 Theoretical Method for Estimating Bone Permeability; 4.3.1 Quantification of Canalicular Anisotropy; 4.3.2 Estimation of Trabecular Bone Permeability; 4.4 Application to Confocal Laser Scanning Imaging.
4.4.1 Quantification of Canalicular Anisotropy4.4.2 Estimation of Trabecular Bone Permeability; 4.5 Validation of the Estimated Bone Permeability; 4.6 Characteristics of the Proposed Estimation Method; 4.7 Conclusion; References; Chapter 5: Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes; 5.1 Introduction; 5.2 Mathematical Model of Trabecular Bone Remodeling; 5.2.1 Theoretical Framework; 5.2.2 Cellular Mechanosensing; 5.2.3 Intercellular Signal Transmission; 5.2.4 Trabecular Surface Movement; 5.3 Voxel Modeling of a Single Trabecula under Cyclic Uniaxial Load.
5.4 Adaptation of a Single Trabecula to Cyclic Uniaxial Load5.4.1 Morphological Changes in Trabecula; 5.4.2 Quantitative Evaluation of Remodeling Process; 5.5 Characteristics of the Proposed Remodeling Model; 5.6 Validity of the Simulated Remodeling Process; 5.7 Conclusion; References; Chapter 6: Effects of Local Bending Load on Trabecular Bone Adaptation; 6.1 Introduction; 6.2 Voxel Modeling of a Single Trabecula under a Cyclic Bending Load; 6.3 Adaptation of a Single Trabecula to a Cyclic Bending Load; 6.4 Role of Local Bending Load in Bone Remodeling; 6.5 Conclusion; References.