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000825794 019__ $$a1020576905$$a1021063261$$a1021203351$$a1027054869
000825794 020__ $$a9783319701974$$q(electronic book)
000825794 020__ $$a3319701975$$q(electronic book)
000825794 020__ $$z9783319701950
000825794 020__ $$z3319701959
000825794 0247_ $$a10.1007/978-3-319-70197-4$$2doi
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000825794 049__ $$aISEA
000825794 050_4 $$aRC280.B8
000825794 08204 $$a616.99/44906$$223
000825794 24500 $$aOptimizing breast cancer management /$$cWilliam J. Gradishar, editor.
000825794 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000825794 300__ $$a1 online resource.
000825794 336__ $$atext$$btxt$$2rdacontent
000825794 337__ $$acomputer$$bc$$2rdamedia
000825794 338__ $$aonline resource$$bcr$$2rdacarrier
000825794 347__ $$atext file$$bPDF$$2rda
000825794 4901_ $$aCancer treatment and research ;$$vvolume 173
000825794 504__ $$aIncludes bibliographical references.
000825794 5050_ $$aIntro; Contents; 1 Strategies to Maintain Fertility in Young Breast Cancer Patients; Abstract; 1.1 Background; 1.2 Effects of Cancer Treatment on Fertility; 1.2.1 Oocyte Development and Fertility; 1.2.2 Chemotherapy; 1.2.3 Endocrine Therapies; 1.2.4 Bioimmune Therapy; 1.2.5 Radiation Therapy; 1.3 Oocyte and Embryo Cryopreservation; 1.3.1 Overview of Controlled Ovarian Stimulation; 1.3.2 Random-Start Protocols; 1.3.3 Use of Adjunct Aromatase Inhibitor; 1.3.4 Ovarian Hyperstimulation Syndrome; 1.4 Ovarian Suppression; 1.5 Ovarian Tissue Cryopreservation; 1.6 In Vitro Oocyte Maturation.
000825794 5058_ $$a1.7 ConclusionReferences; 2 Adjuvant Endocrine Therapy; Abstract; 2.1 Introduction; 2.2 Biomarkers in HR-Positive Breast Cancer; 2.2.1 Hormone Receptors; 2.2.2 Molecular Profiling; 2.2.2.1 Molecular Profiling at Initial Diagnosis; 2.2.2.2 Molecular Profiling to Determine Benefit of Extended Adjuvant Endocrine Therapy; 2.3 Adjuvant Endocrine Therapy; 2.3.1 Menopausal Status; 2.3.2 Endocrine Therapy Classification; 2.3.2.1 Selective Estrogen Receptor Modulators; 2.3.2.2 Aromatase Inhibitors; 2.3.2.3 Ovarian Suppression; 2.3.3 Choice of Therapy Based on Menopausal Status.
000825794 5058_ $$a2.3.3.1 Premenopausal Women2.3.3.2 Postmenopausal Women; 2.3.4 Duration of Therapy; 2.3.5 Male Breast Cancer; 2.3.6 Future Directions; 2.4 Conclusions; References; 3 Breast Cancer Screening: The Debate that Never Ends; Abstract; 3.1 Introduction; 3.2 United States Preventive Services Task Force (USPSTF); 3.3 American Cancer Society (ACS); 3.4 National Comprehensive Cancer Network (NCCN); 3.5 Discussion; References; 4 Management of the Axilla in Early Breast Cancer; Abstract; 4.1 Introduction; 4.2 History of Axillary Surgery; 4.3 Technical Considerations of SLNB; 4.4 The SLN Era.
000825794 5058_ $$a4.4.1 Clinically Node-Negative Proof of Concept4.4.2 Clinically Node Negative with Positive SLNB; 4.5 Challenging Scenarios and Unanswered Questions; 4.5.1 Prophylactic Mastectomy; 4.5.2 Ductal Carcinoma in Situ; 4.5.3 Multicentric Lesions; 4.5.4 Elderly and Axillary Staging; 4.5.5 Prior Breast or Axillary Surgery; 4.5.6 Pregnancy; 4.6 Conclusion; References; 5 Is DCIS Overrated?; Abstract; 5.1 Introduction; 5.2 Anatomy; 5.3 Historical Perspectives on Natural History of DCIS; 5.4 Ductal Carcinoma in Situ and Invasive Ductal Carcinoma.
000825794 5058_ $$a5.5 Clinical, Genomic, and Molecular Characteristics of DCIS5.6 Models of Invasion; 5.7 Incidence; 5.8 Natural History of DCIS; 5.9 Patient Perception of Risk and Treatment Choice; 5.10 Role of Radiation in DCIS; 5.11 Tools for Predicting Class in DCIS Treated with Breast Conservation; 5.12 Conclusion; References; 6 Readdressing the Role of Surgery of the Primary Tumor in de Novo Stage IV Breast Cancer; Abstract; 6.1 Introduction; 6.2 Arguments for Local Therapy to the Primary Tumor; 6.3 Review of Retrospective Studies on Resection of Primary Tumor; 6.4 Bias in Retrospective Studies.
000825794 506__ $$aAccess limited to authorized users.
000825794 520__ $$aThis book presents expert opinions on a variety of key topics related to the management of breast cancer, with a focus on the implications of recent advances and research findings for clinical practice. It also explores the controversy regarding mammography screening and reviews the contribution of new imaging modalities. Considerable attention is paid to developments in surgical procedures, including the potential for the safe and effective use of sentinel lymph node dissection alone?even in patients with positive nodes?and to the advantages and contraindications of new radiotherapy techniques. Genetic aspects are discussed in detail, including an assessment of the role of genetic testing and the potential impact of genetic signatures on breast cancer management. New systemic strategies, such as anti-HER2 therapy, endocrine agents, and agents to reverse endocrine resistance, are considered, and the optimal use of chemotherapy for early-stage and advanced-stage disease is addressed. In closing, the book shares important new insights into lifestyle risk factors, risk reduction strategies, and survivor issues, including sexual dysfunction and fertility maintenance.
000825794 588__ $$aOnline resource; title from PDF title page (viewed January 25, 2018).
000825794 650_0 $$aBreast$$xCancer$$xTreatment.
000825794 7001_ $$aGradishar, William J.,$$eeditor.
000825794 77608 $$iPrint version:$$tOptimizing breast cancer management.$$dCham, Switzerland : Springer, 2018$$z3319701959$$z9783319701950$$w(OCoLC)1005188497
000825794 830_0 $$aCancer treatment and research ;$$vv. 173.
000825794 852__ $$bebk
000825794 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-70197-4$$zOnline Access$$91397441.1
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000825794 980__ $$aEBOOK
000825794 980__ $$aBIB
000825794 982__ $$aEbook
000825794 983__ $$aOnline
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