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000826185 019__ $$a1027054613$$a1029061058$$a1029063138
000826185 020__ $$a9783319716145$$q(electronic book)
000826185 020__ $$a331971614X$$q(electronic book)
000826185 020__ $$z9783319716121
000826185 0247_ $$a10.1007/978-3-319-71614-5$$2doi
000826185 035__ $$aSP(OCoLC)on1022117482
000826185 035__ $$aSP(OCoLC)1022117482$$z(OCoLC)1027054613$$z(OCoLC)1029061058$$z(OCoLC)1029063138
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000826185 049__ $$aISEA
000826185 050_4 $$aQH430
000826185 08204 $$a571.6/6$$223
000826185 24500 $$aNuclear pore complexes in genome organization, function and maintenance /$$cMaximiliano D'Angelo, editor.
000826185 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000826185 300__ $$a1 online resource (viii, 240 pages) :$$bcolor illustrations
000826185 336__ $$atext$$btxt$$2rdacontent
000826185 337__ $$acomputer$$bc$$2rdamedia
000826185 338__ $$aonline resource$$bcr$$2rdacarrier
000826185 347__ $$atext file$$bPDF$$2rda
000826185 5050_ $$aIntro; Preface; Contents; 1 Spatial Organization of the Nucleus Compartmentalizes and Regulates the Genome; 1.1 Introduction; 1.2 Subdomains of the Nucleus; 1.2.1 Nuclear Envelope; 1.2.2 Nuclear Pore Complexes; 1.2.3 Chromosomes; 1.2.4 Centromeres; 1.2.5 Telomeres; 1.2.6 Nucleolus; 1.2.7 Perinucleolar Compartment; 1.2.8 Cajal Bodies; 1.2.9 Gemini of Coiled Bodies; 1.2.10 PML/ND10 Bodies; 1.2.11 Speckles; 1.2.12 Paraspeckles; 1.2.13 Histone Bodies; 1.2.14 Polycomb Bodies; 1.3 Composition of Nuclear Structures; 1.3.1 Mass Spectrometry Opens a Whole New Dimension in Defining Nuclear Subdomains.
000826185 5058_ $$a1.4 Self-Assembly of Nuclear Structures1.5 Genome Organization Patterns; 1.5.1 Loops and Topologically-Associated Domains; 1.5.2 Compartments; 1.6 Structure-Function Relationships; 1.6.1 Layers of Functional Separation; 1.6.2 Loops; 1.6.3 Scaffolds; 1.6.4 Boundary Elements; 1.7 General versus Tissue- or State-Specific Functions; 1.8 Conclusions and Open Questions; 1.8.1 Mechanism for Establishment and Function of Different Organizational Patterns; 1.8.2 Zip Codes and Dynamics; 1.8.3 Conclusions; References.
000826185 5058_ $$a2 The Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome2.1 The Conservation of the Spatial Positioning of the Genome Across Eukaryotes; 2.2 Integral INM Proteins; 2.3 A Brief History of INM Targeting; 2.4 The Nuclear Lamina; 2.5 Lamina Associated Domains; 2.6 LADs as Developmentally Regulated Regions; 2.7 Histone Modifications at the Nuclear Periphery; 2.8 Peripheral Tethers; 2.9 Lamina Associated Sequences; 2.10 Beyond Silencing: The Periphery and Genome Integrity; 2.11 Repetitive DNA and the Nuclear Periphery.
000826185 5058_ $$a2.12 Inputs of Nuclear Compartmentalization on DNA Repair Mechanisms2.13 Outlook; References; 3 Nuclear Pore Complexes: Fascinating Nucleocytoplasmic Checkpoints; 3.1 Introduction; 3.2 Versatility of the NPCs Structural Configuration; 3.3 Composition, Heterogeneity and Dynamics of the NPCs; 3.4 NPCs as Fascinating Gatekeepers Between the Cytoplasm and the Nucleus; 3.5 Configuration and Functional Mechanisms of the Selective NPC Barrier: FG-Nups; References; 4 Nuclear Pore Complex in Genome Organization and Gene Expression in Yeast; 4.1 Introduction.
000826185 5058_ $$a4.2 Spatial Organization of the Yeast Genome4.3 Composition of NPC; 4.4 Nuclear Pore Complex Interacts with the Genome; 4.5 Nups Influence Transcription; 4.6 Mechanisms of Gene Recruitment; 4.7 Interchromosomal Clustering at the NPC; 4.8 Regulation of Gene Recruitment and Clustering; 4.9 Gene Recruitment and Clustering Through the Cell Cycle; 4.10 Transcription Memory; 4.11 Molecular Mechanism of INO1 Transcriptional Memory; 4.12 Concluding Remarks; References; 5 Nuclear Pore and Genome Organization and Gene Expression in Drosophila; 5.1 Introduction.
000826185 506__ $$aAccess limited to authorized users.
000826185 520__ $$aThe three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
000826185 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 7, 2018).
000826185 650_0 $$aEukaryotic cells$$xGenetics.
000826185 650_0 $$aCell nuclei.
000826185 7001_ $$aD'Angelo, Maximiliano,$$eeditor.
000826185 77608 $$iPrint version: $$z9783319716121
000826185 852__ $$bebk
000826185 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-71614-5$$zOnline Access$$91397441.1
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000826185 980__ $$aEBOOK
000826185 980__ $$aBIB
000826185 982__ $$aEbook
000826185 983__ $$aOnline
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