Natural antimicrobial agents / Jean-Michel Mérillon, Céline Rivière, editors.
Merillon, J. M., editor.; Riviere, Céline, editor.
2018
RM267
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Title Natural antimicrobial agents / Jean-Michel Mérillon, Céline Rivière, editors.
ISBN 9783319670454 (electronic book)
331967045X (electronic book)
9783319670430
3319670433
DOI https://doi.org/10.1007/978-3-319-67045-4
Published Cham, Switzerland : Springer, 2018.
Language English
Description 1 online resource (xi, 337 pages) : illustrations.
Item Number 10.1007/978-3-319-67045-4 doi
Call Number RM267
Dewey Decimal Classification 615.7/92
Summary Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Note Includes index.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (SpringerLink, viewed February 14, 2018).
Added Author Merillon, J. M., editor.
Riviere, Céline, editor.
Series Sustainable development and biodiversity (Springer (Firm)) ; v. 19.
Available in Other Form Natural antimicrobial agents.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Intro; Preface; Plant Kingdom and Biodiversity: An Endless Source of Antimicrobials in Human and Plant Health; Contents; Contributors; Plants as a Source of Antibacterials (Human Health); 1 Antimicrobial Natural Products Against Campylobacter; Abstract; 1.1 Introduction; 1.1.1 Campylobacter Contamination and Infection; 1.1.2 Campylobacter Control; 1.2 Natural Products Inhibiting Growth of Campylobacter; 1.2.1 Methods for Identification of Antimicrobial resistance Activity; 1.2.2 Anti-Campylobacter Activity of Isolated Plant Compounds.

1.3 Resistance Modulators and Campylobacter Efflux Pump Inhibitors from Natural Sources1.3.1 Methods for Screening of Resistance Modulators and Efflux Inhibitors; 1.3.2 Natural Products as Campylobacter Resistance Modulators; 1.3.3 Natural Products as Campylobacter Efflux Pump Inhibitors; 1.4 Inhibition of Adhesion and Biofilm Formation of Campylobacter by Natural Products; 1.4.1 Methods for Identification of Adhesion; 1.4.2 Natural Products as Campylobacter Anti-adhesives; 1.5 Antimicrobial Activity of Natural Products Against Campylobacter spp. in Food and Food Production; 1.6 Conclusions.

AcknowledgementsReferences; 2 An Overview of the Antimicrobial Properties of Hop; Abstract; 2.1 Botany, Culture and Uses; 2.2 Phytochemistry; 2.2.1 Essential Oil Components; 2.2.2 Prenylated Phenolic Compounds; 2.2.3 Other Phenolic Compounds; 2.3 Antimicrobial Potential of Hopâ#x80;#x99;s Constituents; 2.3.1 Antibacterial Activity; 2.3.2 Antifungal Activity; 2.3.3 Antiviral Activity; 2.3.4 Antiparasitic Activity; 2.4 Safety and Bioavailability of Active Compounds; 2.5 Industrial Applications; 2.6 Conclusion; References.

3 How to Study Antimicrobial Activities of Plant Extracts: A Critical Point of ViewAbstract; 3.1 Introduction; 3.2 In Vitro Studies; 3.2.1 Studied Concentration; 3.2.2 Solvents; 3.2.3 Choice of Microorganism; 3.2.4 Microbial Analysis; 3.2.4.1 Culture Media; 3.2.4.2 Diffusion Tests; 3.2.4.3 MIC, MBC; 3.2.4.4 Kill Time; 3.2.4.5 Bacterial Growth at Sub-inhibitory Concentrations; 3.2.4.6 Post-antibiotic Effect; 3.2.4.7 Synergy; 3.3 Inhibition of Virulence Factors; 3.3.1 Anti-biofilm Action; 3.3.2 Anti-adhesion Formation; 3.3.3 Anti-toxin Formation; 3.4 Elucidating Mechanisms of Action.

3.5 In Vivo Studies3.5.1 Experimental Infections in Animals; 3.6 Bio-Guided Purification of Active Compounds: Bioautography; 3.7 Conclusion; References; Natural Occurring Antifungal Natural Products (Plant Health); 4 Antifungal Activities of Essential Oils from Himalayan Plants; Abstract; 4.1 Introduction; 4.2 Phytochemistry of Essential Oils; 4.2.1 Plant Collection; 4.2.2 Essential Oil Extraction; 4.2.3 Chemical Analysis; 4.3 Essential Oils as Antifungal Agents; 4.3.1 The Methods Used for Antifungal Activity; 4.3.1.1 Poisoned Food Technique.

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