000826362 000__ 02991cam\a2200457Ii\4500 000826362 001__ 826362 000826362 005__ 20230306144357.0 000826362 006__ m\\\\\o\\d\\\\\\\\ 000826362 007__ cr\cn\nnnunnun 000826362 008__ 180219s2018\\\\si\a\\\\ob\\\\000\0\eng\d 000826362 019__ $$a1023858987$$a1024305865$$a1029061073$$a1029061170$$a1030296606 000826362 020__ $$a9789811073472$$q(electronic book) 000826362 020__ $$a9811073473$$q(electronic book) 000826362 020__ $$z9789811073465 000826362 020__ $$z9811073465 000826362 0247_ $$a10.1007/978-981-10-7347-2$$2doi 000826362 035__ $$aSP(OCoLC)on1023576342 000826362 035__ $$aSP(OCoLC)1023576342$$z(OCoLC)1023858987$$z(OCoLC)1024305865$$z(OCoLC)1029061073$$z(OCoLC)1029061170$$z(OCoLC)1030296606 000826362 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dEBLCP$$dYDX$$dOCLCF$$dDKU$$dUAB$$dUPM$$dSNK$$dMERER$$dSTF$$dOCLCO$$dOCLCQ$$dEMM$$dOCLCO 000826362 049__ $$aISEA 000826362 050_4 $$aQP551.5 000826362 08204 $$a572/.64$$223 000826362 1001_ $$aKangueane, Pandjassarame,$$eauthor. 000826362 24510 $$aProtein-protein and domain-domain interactions /$$cPandjassarame Kangueane, Christina Nilofer. 000826362 264_1 $$aSingapore :$$bSpringer,$$c2018. 000826362 300__ $$a1 online resource (xix, 207 pages) :$$billustrations 000826362 336__ $$atext$$btxt$$2rdacontent 000826362 337__ $$acomputer$$bc$$2rdamedia 000826362 338__ $$aonline resource$$bcr$$2rdacarrier 000826362 347__ $$atext file$$bPDF$$2rda 000826362 504__ $$aIncludes bibliographical references. 000826362 506__ $$aAccess limited to authorized users. 000826362 520__ $$aThis book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins. 000826362 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 19, 2018). 000826362 650_0 $$aProtein-protein interactions. 000826362 7001_ $$aNilofer, Christina,$$eauthor. 000826362 77608 $$iPrint version: $$z9811073465$$z9789811073465$$w(OCoLC)1007049012 000826362 852__ $$bebk 000826362 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-10-7347-2$$zOnline Access$$91397441.1 000826362 909CO $$ooai:library.usi.edu:826362$$pGLOBAL_SET 000826362 980__ $$aEBOOK 000826362 980__ $$aBIB 000826362 982__ $$aEbook 000826362 983__ $$aOnline 000826362 994__ $$a92$$bISE