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Cellular and molecular toxicology of nanoparticles / Quaiser Saquib, Mohammad Faisal, Abdulaziz A. Al-Khedhairy, Abdulrahman A. Alatar, editors.

Saquib, Quaiser, editor.; Faisal, Mohammad, editor.; Al-Khedhairy, Abdulaziz A. editor.; Alatar, Abdulrahman A. editor.
2018
RS201.N35
Available Online
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Title
Cellular and molecular toxicology of nanoparticles / Quaiser Saquib, Mohammad Faisal, Abdulaziz A. Al-Khedhairy, Abdulrahman A. Alatar, editors.
ISBN
9783319720418 (electronic book)
3319720414 (electronic book)
9783319720401
3319720406
DOI
https://doi.org/10.1007/978-3-319-72041-8
Published
Cham, Switzerland : Springer, 2018.
Language
English
Description
1 online resource (xvi, 346 pages) : illustrations.
Item Number
10.1007/978-3-319-72041-8 doi
Call Number
RS201.N35
Dewey Decimal Classification
620/.5
Summary
This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called "biomolecular corona". The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.
Note
Includes index.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed February 20, 2018).
Added Author
Saquib, Quaiser, editor.
Faisal, Mohammad, editor.
Al-Khedhairy, Abdulaziz A. editor.
Alatar, Abdulrahman A. editor.
Series
Advances in experimental medicine and biology ; v. 1048.
Available in Other Form
Print version: 9783319720401
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
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