Multifunctional gold nanostars for cancer theranostics / Yang Liu.
2018
R857.N34
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Details
Title
Multifunctional gold nanostars for cancer theranostics / Yang Liu.
Author
Liu, Yang, author.
ISBN
9783319749204 (electronic book)
331974920X (electronic book)
9783319749198
3319749196
331974920X (electronic book)
9783319749198
3319749196
Published
Cham, Switzerland : Springer, 2018.
Language
English
Description
1 online resource.
Other Standard Identifiers
10.1007/978-3-319-74920-4 doi
Call Number
R857.N34
Dewey Decimal Classification
610.28
Summary
This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model. Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer. The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.
Note
"Doctoral thesis accepted by the Duke University, USA."
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed March 21, 2018).
Series
Springer theses.
Available in Other Form
Print version: 9783319749198
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Table of Contents
Introduction
Multifunctional GNS nanoprobe development and characterization
In vivo evaluation of GNS nanoprobe
GNS toxicity investigation
Sensitive brain tumor detection using GNS nanoprobe
Photoimmunotherapy for cancer metastasis treatment
Conclusion and future outlook.
Multifunctional GNS nanoprobe development and characterization
In vivo evaluation of GNS nanoprobe
GNS toxicity investigation
Sensitive brain tumor detection using GNS nanoprobe
Photoimmunotherapy for cancer metastasis treatment
Conclusion and future outlook.