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000826912 019__ $$a1029076372$$a1029330922$$a1029448212$$a1029479420$$a1029571080$$a1029662361$$a1033635934
000826912 020__ $$a9783319749204$$q(electronic book)
000826912 020__ $$a331974920X$$q(electronic book)
000826912 020__ $$z9783319749198
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000826912 0247_ $$a10.1007/978-3-319-74920-4$$2doi
000826912 035__ $$aSP(OCoLC)on1029054945
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000826912 049__ $$aISEA
000826912 050_4 $$aR857.N34
000826912 08204 $$a610.28$$223
000826912 1001_ $$aLiu, Yang,$$eauthor.
000826912 24510 $$aMultifunctional gold nanostars for cancer theranostics /$$cYang Liu.
000826912 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000826912 300__ $$a1 online resource.
000826912 336__ $$atext$$btxt$$2rdacontent
000826912 337__ $$acomputer$$bc$$2rdamedia
000826912 338__ $$aonline resource$$bcr$$2rdacarrier
000826912 347__ $$atext file$$bPDF$$2rda
000826912 4901_ $$aSpringer theses
000826912 500__ $$a"Doctoral thesis accepted by the Duke University, USA."
000826912 504__ $$aIncludes bibliographical references.
000826912 5050_ $$aIntroduction -- Multifunctional GNS nanoprobe development and characterization -- In vivo evaluation of GNS nanoprobe -- GNS toxicity investigation -- Sensitive brain tumor detection using GNS nanoprobe -- Photoimmunotherapy for cancer metastasis treatment -- Conclusion and future outlook.
000826912 506__ $$aAccess limited to authorized users.
000826912 520__ $$aThis thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model. Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer. The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.
000826912 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 21, 2018).
000826912 650_0 $$aNanomedicine.
000826912 650_0 $$aCancer$$xTreatment$$xTechnological innovations.
000826912 77608 $$iPrint version: $$z9783319749198
000826912 830_0 $$aSpringer theses.
000826912 852__ $$bebk
000826912 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-74920-4$$zOnline Access$$91397441.1
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