Intro; Preface; References; Contents; 475 Chemistry and Structure-Activity Relationships of Psychedelics; Abstract; 1 Introduction; 2 Tryptamines; 2.1 Ring Substituents; 2.2 N-Alkylation; 2.3 Side Chain Alkylation; 3 Ergolines; 3.1 Amide Modifications of Lysergic Acid Derivatives; 3.2 N(6)-Alkyl Modifications of LSD; 4 Ergolines as "Research Chemicals"; 5 Phenethylamines and Related Congeners; 5.1 Beta-Oxygenated Phenethylamines; 5.2 Ring Substituents; 5.3 Methoxy Mimics-Benzofuran and Benzopyran Analogues; 5.4 Effect of Side Chain Alpha-Alkylation

6 Identifying the "Active" Conformation of the Phenethylamines6.1 Effect of an N-Benzyl Group; 6.2 The Active Conformation of N-Benzylphenethylamines; 7 Modeling the Receptor-Ligand Interaction; 8 Conclusion; References; 478 Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways; Abstract; 1 Introduction to Receptor Pharmacology; 2 Serotonin and Serotonin Receptors: A Historical Perspective; 2.1 Serotonin; 2.2 Serotonin Receptors; 3 Chemical Neuroanatomy of 5-HT2A Receptors; 4 Hallucinogenic and Non-Hallucinogenic 5-HT2A Receptor Agonists

5 Biased Agonism at the 5-HT2A Receptor6 Additional Signaling Pathways Modulated by Activation of the 5-HT2A Receptor; 7 Role of mGlu2 Receptor in Hallucinogen Action; 8 Future Directions; Acknowledgements; References; 473 Effects of Hallucinogens on Neuronal Activity; Abstract; 1 Hallucinogens as Pharmacological Models in Schizophrenia Research; 1.1 Serotonergic Hallucinogens; 1.2 NMDA Receptors. Noncompetitive Antagonists; 2 The Prefrontal Cortex; 3 Effects of Psychotomimetic Agents on Neuronal Activity in PFC; 3.1 Serotonergic Hallucinogens; 3.2 Noncompetitive NMDA Receptor Antagonists

4 Role of Thalamocortical Inputs5 Brain Oscillations: Relevance to Schizophrenia; 6 Effects of Psychotomimetic Agents on Low Frequency Cortical Oscillations; 7 Mechanisms Involved in the Reversal by Antipsychotic Drugs; 8 Concluding Remarks; Acknowledgements; References; 480 Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons; Abstract; 1 From 5-HT2A Receptor-Induced EPSCs and Recurrent Neuronal Activity to Salient Behavioral Effects Induced by 5-HT2A Receptor Activation

2 Clinical Relevance of the Interactions Between Glutamate and 5-HT2A Receptors in the mPFC3 Conclusions; References; 479 The Effects of Hallucinogens on Gene Expression; Abstract; 1 Introduction; 2 Immediate Early Genes; 3 IEG and 5-HT2A Receptor Expression: Early Studies; 4 Identification of Tissues that Transcriptionally Respond to Psychedelics: Early Studies; 5 IEG and 5-HT2A Receptor Expression in the Post-Genomic Era; 6 Psychedelics, Gene Expression, and Cellular Signaling; 7 Identification and Characterization of the Cortical Cellular Population Responsive to Psychedelics