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000827578 019__ $$a1012939135$$a1014147608$$a1017773999$$a1017978245$$a1032285074
000827578 020__ $$a9783319503530$$q(electronic book)
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000827578 0247_ $$a10.1007/978-3-319-50353-0
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000827578 24500 $$aAlternatives for dermal toxicity testing /$$cChantra Eskes, Erwin van Vliet, Howard I. Maibach, editors ; foreword by Alan M. Goldberg.
000827578 260__ $$aCham :$$bSpringer,$$c2017.
000827578 300__ $$a1 online resource
000827578 336__ $$atext$$btxt$$2rdacontent
000827578 337__ $$acomputer$$bc$$2rdamedia
000827578 338__ $$aonline resource$$bcr$$2rdacarrier
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000827578 5050_ $$aIntroduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.
000827578 506__ $$aAccess limited to authorized users.
000827578 520__ $$aThis book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
000827578 588__ $$aOnline resource; title from PDF title page (viewed November 30, 2017).
000827578 650_0 $$aAlternative toxicity testing.
000827578 650_0 $$aToxicology$$vMethods.
000827578 650_0 $$aToxicology, Experimental.
000827578 7001_ $$aEskes, Chantra,$$eeditor.
000827578 7001_ $$aVliet, Erwin van,$$eeditor.
000827578 7001_ $$aMaibach, Howard I.,$$eeditor.
000827578 7001_ $$aGoldberg, Alan M.,$$eeditor.
000827578 77608 $$iPrint version: $$z9783319503516
000827578 852__ $$bebk
000827578 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-50353-0$$zOnline Access$$91397441.1
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