000827721 000__ 04842cam\a2200517Ii\4500 000827721 001__ 827721 000827721 005__ 20230306144526.0 000827721 006__ m\\\\\o\\d\\\\\\\\ 000827721 007__ cr\cn\nnnunnun 000827721 008__ 180316s2018\\\\sz\\\\\\ob\\\\000\0\eng\d 000827721 019__ $$a1029205407$$a1029240231$$a1029336288$$a1029445027 000827721 020__ $$a9783319752419$$q(electronic book) 000827721 020__ $$a3319752413$$q(electronic book) 000827721 020__ $$z9783319752402 000827721 020__ $$z3319752405 000827721 035__ $$aSP(OCoLC)on1028747441 000827721 035__ $$aSP(OCoLC)1028747441$$z(OCoLC)1029205407$$z(OCoLC)1029240231$$z(OCoLC)1029336288$$z(OCoLC)1029445027 000827721 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dN$T$$dYDX$$dEBLCP 000827721 049__ $$aISEA 000827721 050_4 $$aQR74.8 000827721 08204 $$a579.3/23$$223 000827721 24500 $$aType IV secretion in gram-negative and gram-positive bacteria /$$cSteffen Backert, Elisabeth Grohmann, editors. 000827721 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018. 000827721 300__ $$a1 online resource. 000827721 336__ $$atext$$btxt$$2rdacontent 000827721 337__ $$acomputer$$bc$$2rdamedia 000827721 338__ $$aonline resource$$bcr$$2rdacarrier 000827721 4901_ $$aCurrent topics in microbiology and immunology ;$$vvolume 413 000827721 504__ $$aIncludes bibliographical references. 000827721 5050_ $$aIntro; Foreword; T4SS-Then and Now; Contents; Abbreviations; 1 Biological Diversity and Evolution of Type IV Secretion Systems; Abstract; 1 Introduction: The ABC's of T4SS Classification; 2 Function, Structure, and Diversification of T4ASS and T4BSSs; 2.1 The VirD4 Receptor and Its Role in Substrate Selection; 2.2 The Role of Accessory Factors in Substrate Recruitment; 2.3 The Inner Membrane Complex (IMC); 2.4 Evolutionary Adaptations of IMC Subunits; 2.5 The Outer Membrane Core Complex (OMCC); 2.6 Evolutionary Adaptations of OMCC Subunits; 3 T4SS-Mediated Modulation of Target Cell Attachment 000827721 5058_ $$a3.1 T4ASS P- and F-pili3.2 Evolutionary Adaptations of T4ASS-Associated Surface Structures; 3.3 T4BSS DNA Transfer and Dot/Icm Systems; 4 Evolution of Dot/Icm Secretion System; 5 Comparisons of Effectors Secreted Through Different Dot/Icm Secretion Systems; 6 Concluding Remarks; Acknowledgements; References; 2 Structural and Molecular Biology of Type IV Secretion Systems; Abstract; 1 Architectures and Functions of Type IV Secretion Systems; 1.1 Classification and Overview; 1.2 Composition of T4SSs; 2 Structures of Individual Components; 2.1 ATPases; 2.1.1 VirB11; 2.1.2 VirD4; 2.1.3 VirB4 000827721 5058_ $$a2.2 Inner Membrane2.2.1 VirB3; 2.2.2 VirB6; 2.2.3 VirB8; 2.3 Outer Membrane and Periplasm; 2.3.1 VirB1; 2.3.2 VirB7 and VirB9; 2.3.3 VirB10; 2.4 Pilus Protein(s); 2.4.1 VirB2; 2.4.2 VirB5; 3 Structures of T4SS Molecular Assemblies; 3.1 The Core (or Outer Membrane) Complex; 3.2 The T4SS3-10 Complex; 3.3 Structure of the Pilus; 4 Mechanism of Substrate Transport; 5 Concluding Remarks; Acknowledgements; References; 3 Prokaryotic Information Games: How and When to Take up and Secrete DNA; Abstract; 1 DNA Secretion by Bacterial Conjugation 000827721 5058_ $$a1.1 Transfer Competence Development and Heterogeneity of Isogenic Populations1.2 Bistability and Excitability in Genetic Networks; 1.3 Non-stochastic Switching to Transfer Competence; 1.3.1 Cell-to-Cell Signaling and Quorum Sensing; 1.3.2 Environmental Signals; 1.4 Stochastic Switching: No Signals and Rules, just Random Amplification of Noise?; 1.4.1 Bet Hedging in Bacterial Conjugation; 2 Bacterial DNA Uptake Competence and Transport Mechanisms; 2.1 Principles of DNA Uptake; 2.1.1 DNA Uptake via a T4SS-How to Take up DNA?; 2.1.2 Components of the ComB T4SS of Helicobacter pylori 000827721 5058_ $$a2.1.3 Visualization of DNA Uptake in Single Cells of Helicobacter pylori2.2 Competence Development-When to Take up DNA?; 2.2.1 Decision Making for Competence Development Is Species-Specific; 2.2.2 How Is Competence Limited in a T4SS-Mediated DNA Uptake System?; 3 Concluding Remarks; References; 4 Relaxases and Plasmid Transfer in Gram-Negative Bacteria; Abstract; 1 Biochemistry of Relaxases; 2 Relaxase-DNA Binding; 3 Relaxosome; 4 Intracellular Trafficking and Relaxase Recruitment to the Conjugative Pore; 5 Bifunctional Relaxase-DNA Helicase Enzymes; 6 Domain-Specific DNA Interactions 000827721 506__ $$aAccess limited to authorized users. 000827721 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 21, 2018). 000827721 650_0 $$aGram-negative bacteria$$xSecretion. 000827721 650_0 $$aGram-positive bacteria$$xSecretion. 000827721 7001_ $$aBackert, Steffen,$$eeditor. 000827721 7001_ $$aGrohmann, Elisabeth,$$eeditor. 000827721 77608 $$iPrint version: $$z3319752405$$z9783319752402$$w(OCoLC)1019607421 000827721 830_0 $$aCurrent topics in microbiology and immunology ;$$v413. 000827721 852__ $$bebk 000827721 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-75241-9$$zOnline Access$$91397441.1 000827721 909CO $$ooai:library.usi.edu:827721$$pGLOBAL_SET 000827721 980__ $$aEBOOK 000827721 980__ $$aBIB 000827721 982__ $$aEbook 000827721 983__ $$aOnline 000827721 994__ $$a92$$bISE