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000838456 019__ $$a1030899306$$a1030968798$$a1033659542$$a1034549217
000838456 020__ $$a9783319719672$$q(electronic book)
000838456 020__ $$a331971967X$$q(electronic book)
000838456 020__ $$z9783319719665
000838456 020__ $$z3319719661
000838456 0247_ $$a10.1007/978-3-319-71967-2$$2doi
000838456 035__ $$aSP(OCoLC)on1030892344
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000838456 049__ $$aISEA
000838456 050_4 $$aRG135
000838456 08204 $$a618.178
000838456 24500 $$aRecurrent implantation failure :$$betiologies and clinical management /$$cJason M. Franasiak, Richard T. Scott Jr., editors.
000838456 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000838456 300__ $$a1 online resource
000838456 336__ $$atext$$btxt$$2rdacontent
000838456 337__ $$acomputer$$bc$$2rdamedia
000838456 338__ $$aonline resource$$bcr$$2rdacarrier
000838456 347__ $$atext file$$bPDF$$2rda
000838456 500__ $$aIncludes index.
000838456 5050_ $$aIntro; Preface; Contents; Contributors; Recurrent Implantation Failure; Chapter 1: Signaling Between Embryo and Endometrium: Normal Implantation; Timing of Implantation; The Endometrium; Endometrial Receptivity; Histologic Dating; Adhesion Molecules; Growth Factors and Cytokines; Matrix Metalloproteinases; HOX Genes; Prostaglandins; Cytokines; Theories of Endometrial Receptivity Defects; Summary and Conclusions; References; Chapter 2: Embryo and Endometrial Synchrony in Implantation Failure; Introduction; Pathology or Physiology; The Endometrium; The Embryo.
000838456 5058_ $$aManagement of Embryo and Endometrial SynchronySummary; References; Chapter 3: Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?; Male Gamete Factor, Why it Matters?; Major Male Gamete Factors in Recurrent Implantation Failure; Sperm Chromosomal Aneuploidy; Sperm DNA Damage/Sperm DNA Fragmentation (SDF); Sperm Epigenetics; Potential Therapeutic Options and Interventions; Future Directions; References; Chapter 4: Embryonic Factors Associated with Recurrent Implantation Failure; Cleavage Stage Embryos.
000838456 5058_ $$aDevelopmental Rate and Abnormal Kinetics in the Cleavage Stage EmbryoMorphologic Features Associated with Implantation at the Cleavage Stage; Laboratory Interventions to Improve Implantation Potential at the Cleavage Stage; Time-Lapse Imaging for Detection of Abnormal Cleavage Patterns, Abnormal Phenotypes, and Multinucleated Embryos; Assisted Hatching for Treatment of the Thick Zona Pellucida; Co-culture of Embryos; Extended Culture of Embryos to the Blastocyst Stage; Blastocyst Stage Embryos; Developmental Rate and Abnormal Kinetics in the Blastocyst.
000838456 5058_ $$aMorphologic Features of the Blastocyst Associated with ImplantationLaboratory Interventions to Improve Implantation Potential at the Blastocyst Stage; Freeze-All Strategy; Vitrification of Blastocysts Undergoing Delayed Expansion; Other Emerging Treatment Options; Conclusions; References; Chapter 5: The Genetics of Pregnancy Failure; The Role of Genetics in Early Pregnancy Failure; Cytogenetic Findings in POCs; Chromosome Rearrangement History; Single Gene Disorders and Recurrent Pregnancy Loss; The Role of Genetics in Implantation.
000838456 5058_ $$aPreimplantation Genetic Screening (PGS): First Generation, Limited by Suboptimal Biopsy and Testing MethodologyPreimplantation Genetic Screening: Second Generation, Improved Biopsy, and Comprehensive Testing Platforms; Conclusion; References; Chapter 6: Immune Factors in Recurrent Implantation Failure; Natural Killer Cells; But What Happens in ART?; Other Immune Maternal Cells; Conclusions; References; Chapter 7: Stress and Implantation Failure; Stress-Induced Suppression of Folliculogenesis as a Cause of Implantation Failure; Stress and FHA.
000838456 506__ $$aAccess limited to authorized users.
000838456 520__ $$aThis unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists.
000838456 588__ $$aOnline resource; title from PDF title page (viewed  April 10, 2018).
000838456 650_0 $$aHuman embryo$$xTransplantation.
000838456 650_0 $$aInfertility, Female.
000838456 650_0 $$aHuman reproductive technology.
000838456 7001_ $$aFranasiak, Jason M.,$$eeditor.
000838456 7001_ $$aScott, Richard T.,$$eeditor.
000838456 77608 $$iPrint version:$$tRecurrent implantation failure.$$dCham, Switzerland : Springer, 2018$$z3319719661$$z9783319719665$$w(OCoLC)1009057307
000838456 852__ $$bebk
000838456 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-71967-2$$zOnline Access$$91397441.1
000838456 909CO $$ooai:library.usi.edu:838456$$pGLOBAL_SET
000838456 980__ $$aEBOOK
000838456 980__ $$aBIB
000838456 982__ $$aEbook
000838456 983__ $$aOnline
000838456 994__ $$a92$$bISE