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Intro; Preface; Contents; Contributors; Recurrent Implantation Failure; Chapter 1: Signaling Between Embryo and Endometrium: Normal Implantation; Timing of Implantation; The Endometrium; Endometrial Receptivity; Histologic Dating; Adhesion Molecules; Growth Factors and Cytokines; Matrix Metalloproteinases; HOX Genes; Prostaglandins; Cytokines; Theories of Endometrial Receptivity Defects; Summary and Conclusions; References; Chapter 2: Embryo and Endometrial Synchrony in Implantation Failure; Introduction; Pathology or Physiology; The Endometrium; The Embryo.
Management of Embryo and Endometrial SynchronySummary; References; Chapter 3: Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?; Male Gamete Factor, Why it Matters?; Major Male Gamete Factors in Recurrent Implantation Failure; Sperm Chromosomal Aneuploidy; Sperm DNA Damage/Sperm DNA Fragmentation (SDF); Sperm Epigenetics; Potential Therapeutic Options and Interventions; Future Directions; References; Chapter 4: Embryonic Factors Associated with Recurrent Implantation Failure; Cleavage Stage Embryos.
Developmental Rate and Abnormal Kinetics in the Cleavage Stage EmbryoMorphologic Features Associated with Implantation at the Cleavage Stage; Laboratory Interventions to Improve Implantation Potential at the Cleavage Stage; Time-Lapse Imaging for Detection of Abnormal Cleavage Patterns, Abnormal Phenotypes, and Multinucleated Embryos; Assisted Hatching for Treatment of the Thick Zona Pellucida; Co-culture of Embryos; Extended Culture of Embryos to the Blastocyst Stage; Blastocyst Stage Embryos; Developmental Rate and Abnormal Kinetics in the Blastocyst.
Morphologic Features of the Blastocyst Associated with ImplantationLaboratory Interventions to Improve Implantation Potential at the Blastocyst Stage; Freeze-All Strategy; Vitrification of Blastocysts Undergoing Delayed Expansion; Other Emerging Treatment Options; Conclusions; References; Chapter 5: The Genetics of Pregnancy Failure; The Role of Genetics in Early Pregnancy Failure; Cytogenetic Findings in POCs; Chromosome Rearrangement History; Single Gene Disorders and Recurrent Pregnancy Loss; The Role of Genetics in Implantation.
Preimplantation Genetic Screening (PGS): First Generation, Limited by Suboptimal Biopsy and Testing MethodologyPreimplantation Genetic Screening: Second Generation, Improved Biopsy, and Comprehensive Testing Platforms; Conclusion; References; Chapter 6: Immune Factors in Recurrent Implantation Failure; Natural Killer Cells; But What Happens in ART?; Other Immune Maternal Cells; Conclusions; References; Chapter 7: Stress and Implantation Failure; Stress-Induced Suppression of Folliculogenesis as a Cause of Implantation Failure; Stress and FHA.
Management of Embryo and Endometrial SynchronySummary; References; Chapter 3: Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?; Male Gamete Factor, Why it Matters?; Major Male Gamete Factors in Recurrent Implantation Failure; Sperm Chromosomal Aneuploidy; Sperm DNA Damage/Sperm DNA Fragmentation (SDF); Sperm Epigenetics; Potential Therapeutic Options and Interventions; Future Directions; References; Chapter 4: Embryonic Factors Associated with Recurrent Implantation Failure; Cleavage Stage Embryos.
Developmental Rate and Abnormal Kinetics in the Cleavage Stage EmbryoMorphologic Features Associated with Implantation at the Cleavage Stage; Laboratory Interventions to Improve Implantation Potential at the Cleavage Stage; Time-Lapse Imaging for Detection of Abnormal Cleavage Patterns, Abnormal Phenotypes, and Multinucleated Embryos; Assisted Hatching for Treatment of the Thick Zona Pellucida; Co-culture of Embryos; Extended Culture of Embryos to the Blastocyst Stage; Blastocyst Stage Embryos; Developmental Rate and Abnormal Kinetics in the Blastocyst.
Morphologic Features of the Blastocyst Associated with ImplantationLaboratory Interventions to Improve Implantation Potential at the Blastocyst Stage; Freeze-All Strategy; Vitrification of Blastocysts Undergoing Delayed Expansion; Other Emerging Treatment Options; Conclusions; References; Chapter 5: The Genetics of Pregnancy Failure; The Role of Genetics in Early Pregnancy Failure; Cytogenetic Findings in POCs; Chromosome Rearrangement History; Single Gene Disorders and Recurrent Pregnancy Loss; The Role of Genetics in Implantation.
Preimplantation Genetic Screening (PGS): First Generation, Limited by Suboptimal Biopsy and Testing MethodologyPreimplantation Genetic Screening: Second Generation, Improved Biopsy, and Comprehensive Testing Platforms; Conclusion; References; Chapter 6: Immune Factors in Recurrent Implantation Failure; Natural Killer Cells; But What Happens in ART?; Other Immune Maternal Cells; Conclusions; References; Chapter 7: Stress and Implantation Failure; Stress-Induced Suppression of Folliculogenesis as a Cause of Implantation Failure; Stress and FHA.