000838568 000__ 04135cam\a2200445Ii\4500 000838568 001__ 838568 000838568 005__ 20230306144549.0 000838568 006__ m\\\\\o\\d\\\\\\\\ 000838568 007__ cr\un\nnnunnun 000838568 008__ 180413s2018\\\\sz\\\\\\ob\\\\001\0\eng\d 000838568 020__ $$a9783319893006$$q(electronic book) 000838568 020__ $$a3319893009$$q(electronic book) 000838568 020__ $$z9783319892993 000838568 035__ $$aSP(OCoLC)on1031214427 000838568 035__ $$aSP(OCoLC)1031214427 000838568 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dEBLCP$$dOCLCF$$dUAB$$dOCLCQ 000838568 049__ $$aISEA 000838568 050_4 $$aQL55 000838568 08204 $$a636.0885 000838568 1001_ $$aLauwereyns, Jan,$$eauthor. 000838568 24510 $$aRethinking the three R's in animal research :$$breplacement, reduction, refinement /$$cJan Lauwereyns. 000838568 264_1 $$aCham, Switzerland :$$bPalgrave MacMillan,$$c2018. 000838568 300__ $$a1 online resource. 000838568 336__ $$atext$$btxt$$2rdacontent 000838568 337__ $$acomputer$$bc$$2rdamedia 000838568 338__ $$aonline resource$$bcr$$2rdacarrier 000838568 504__ $$aIncludes bibliographical references and index. 000838568 5050_ $$aIntro; Contents; Chapter 1 Introduction; Abstract; 1.1 Building on the Legacy of Russell and Burch (1959/1992); 1.2 Four Movements to the Argument; 1.3 Full Disclosure; References; Chapter 2 Concept Fatigue with the Three R's; Abstract; 2.1 The Original Work by Russell and Burch (1959/1992) in Context; 2.1.1 On the Removal of Inhumanity; 2.1.2 Humane Versus Speciesist; 2.1.3 The Actual Definitions; 2.1.3.1 Replacement; 2.1.3.2 Reduction; 2.1.3.3 Refinement; 2.2 Changing Perspectives on the Use of Animals; 2.2.1 No Magic Dust; 2.2.2 For the Animal's Sake 000838568 5058_ $$a2.2.3 The Monkey Eye-Movement Paradigm Then and NowReferences; Chapter 3 A Mismatch Between Micro-motives and Macro-behavior; Abstract; 3.1 Analyzing Aggregate Behavior; 3.1.1 Three Classic Examples of Micro-Macro Conflict; 3.1.1.1 The Prisoner's Dilemma; 3.1.1.2 The Tragedy of the Commons; 3.1.1.3 The Case of the Two Dining Rooms; 3.1.2 Applying the Micro-Macro Analysis to Animal Research; 3.1.2.1 The Individual Researcher's Perspective; 3.1.2.2 Failure of the Three R's at the Macroscopic Level; 3.1.2.3 Scale Enlargement for More with Less; 3.1.2.4 Public Support as a Limited Resource 000838568 5058_ $$a3.2 The Principles of Reasonable Experimental Inquiry3.2.1 On the Valuation of Research; 3.2.2 The Preferred Animal Model; 3.2.3 New Definitions; 3.2.3.1 Replacement; 3.2.3.2 Reduction; 3.2.3.3 Refinement; References; Chapter 4 The Monkey Question; Abstract; 4.1 A Critique of Arguments; 4.1.1 The Past Is Not Always a Good Model for the Future; 4.1.2 Misleading Claims of Necessity; 4.1.3 An Erroneous Preference for Nonhuman Primates; 4.1.4 A Prejudice Against Replacement with Other Animals; 4.2 Examples of (Missed) Replacement Opportunities; 4.2.1 Real-Time Control of a Robot Arm 000838568 5058_ $$a4.2.2 Perceptual Decision-Making4.2.3 Cognitive Mechanisms of Cocaine Addiction; References; Chapter 5 Toward Reasonable Experimental Inquiry; Abstract; 5.1 Replacement as the Critical R; 5.1.1 Eyes Open to Opportunity Costs; 5.1.2 Real-World Barriers to Replacement; 5.1.3 A Shift in Agency; 5.2 Practical Wisdom, Informed and Integrative; 5.2.1 Open Science; 5.2.2 Big Science; 5.2.3 Free Thought and Coordinated Action; 5.3 The Sleep of Reason Produces Monsters; References; Index 000838568 506__ $$aAccess limited to authorized users. 000838568 520__ $$aThis work challenges the current reliance on "The Three R's" or Replacement, Reduction and Refinement which direct most animal research in the behavioral sciences. The author argues that these principles that were developed in the 1950's to guide the use of animals in research studies are outdated. He suggests that the notions of refinement and reduction are often ill-defined and can be useful only in cases where replacement is impossible. 000838568 588__ $$aOnline resource; title from PDF title page (viewed April 16, 2018). 000838568 650_0 $$aLaboratory animals$$xResearch. 000838568 650_0 $$aMedicine$$xResearch. 000838568 852__ $$bebk 000838568 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-89300-6$$zOnline Access$$91397441.1 000838568 909CO $$ooai:library.usi.edu:838568$$pGLOBAL_SET 000838568 980__ $$aEBOOK 000838568 980__ $$aBIB 000838568 982__ $$aEbook 000838568 983__ $$aOnline 000838568 994__ $$a92$$bISE