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Intro; Foreword to the First Edition; Preface to the First Edition; Preface to the Second Edition; Acknowledgments; Contents; Contributors; Part I: Physiology, Pathophysiology and Pharmacology of Liver Disease; 1: Physiology and Anatomy of the Liver; Introduction; Embryology; Macroscopic Anatomy of the Liver and the Visceral Circulation; Histology; Cellular Classification; Anatomic Lobules and Metabolic Zones; Immunological Function of the Liver; Innate and Adaptive Immunity; Oral and Allograft Tolerance; Hepatic Drug Metabolism; First Pass Metabolism
Phase II and III Metabolism, Phase 0 and III TransportSubstrates, Inducers and Inhibitors of P450 System: Implications for Toxicity and Therapeutic Failure; Hepatic Glucose, Amino Acid, and Lipid Metabolism; Glucose Homeostasis; Protein Metabolism and Hepatic Encephalopathy; Lipid Metabolism and Nonalcoholic Fatty Liver Disease; Liver Coagulation and Fibrinolysis; Hepatic Endocrine Function; References; 2: Chronic Liver Failure and Hepatic Cirrhosis; Introduction; Epidemiology; Etiologies; Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis; Alcohol-Related Liver Disease
Hepatitis B VirusHepatitis C Virus; Pathophysiology; Liver Injury; Fibrosis; Hepatocellular Dysfunction and Portal Hypertension; Clinical Presentation and Complications; Synthetic Dysfunction; Portal Hypertension; Ascites; Spontaneous Bacterial Peritonitis; Hepatic Hydrothorax; Esophageal Varices; Portosystemic Encephalopathy; Hepatopulmonary Syndrome; Portopulmonary Hypertension; Hepatorenal Syndrome; Cirrhotic Cardiomyopathy; Portal Vein Thrombosis; Hepatocellular Carcinoma; Prognosis and Risk Stratification; Prognosis; Child-Turcotte-Pugh Scoring System; Model for End-Stage Liver Disease
Treatment of CirrhosisGeneral Management Strategies; Indications for Liver Transplantation; Antifibrotic Therapies; Targets for Antifibrotic Agents; References; 3: Acute Hepatic Failure; Introduction; Classification of ALF; Etiologies of ALF; Paracetamol (Acetominophen) Overdose; Viral Hepatitis; Idiosyncratic Drug Reaction; Seronegative (Indeterminate); Malignancy; Vascular Insults and Ischemic Hepatitis; Metabolic; Autoimmune Hepatitis; Miscellaneous; Clinical Features and General Management; Cardiovascular; Respiratory; Neurological; Metabolic, Gastroenterology and Nutrition
Immunity and BacteremiaAcute Kidney Injury; Coagulation; Prognosis of ALF; King's College Criteria; Clichy Criteria; MELD and Liver Volumes; Contraindications to Liver Transplantation; Summary; References; 4: The Splanchnic and Systemic Circulation in Liver Disease; Introduction; Physiology; Portal Pressure and Hypertension; The Role of Vasopressin in Liver Disease; Summary; References; 5: Drug Metabolism in Liver Failure; Introduction; Pharmacokinetics (PK) and Pharmacodynamics (PD); Effect of Liver Faiure on Medication PK and PD; Absorption; Protein Binding and Distribution; Metabolism
Phase II and III Metabolism, Phase 0 and III TransportSubstrates, Inducers and Inhibitors of P450 System: Implications for Toxicity and Therapeutic Failure; Hepatic Glucose, Amino Acid, and Lipid Metabolism; Glucose Homeostasis; Protein Metabolism and Hepatic Encephalopathy; Lipid Metabolism and Nonalcoholic Fatty Liver Disease; Liver Coagulation and Fibrinolysis; Hepatic Endocrine Function; References; 2: Chronic Liver Failure and Hepatic Cirrhosis; Introduction; Epidemiology; Etiologies; Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis; Alcohol-Related Liver Disease
Hepatitis B VirusHepatitis C Virus; Pathophysiology; Liver Injury; Fibrosis; Hepatocellular Dysfunction and Portal Hypertension; Clinical Presentation and Complications; Synthetic Dysfunction; Portal Hypertension; Ascites; Spontaneous Bacterial Peritonitis; Hepatic Hydrothorax; Esophageal Varices; Portosystemic Encephalopathy; Hepatopulmonary Syndrome; Portopulmonary Hypertension; Hepatorenal Syndrome; Cirrhotic Cardiomyopathy; Portal Vein Thrombosis; Hepatocellular Carcinoma; Prognosis and Risk Stratification; Prognosis; Child-Turcotte-Pugh Scoring System; Model for End-Stage Liver Disease
Treatment of CirrhosisGeneral Management Strategies; Indications for Liver Transplantation; Antifibrotic Therapies; Targets for Antifibrotic Agents; References; 3: Acute Hepatic Failure; Introduction; Classification of ALF; Etiologies of ALF; Paracetamol (Acetominophen) Overdose; Viral Hepatitis; Idiosyncratic Drug Reaction; Seronegative (Indeterminate); Malignancy; Vascular Insults and Ischemic Hepatitis; Metabolic; Autoimmune Hepatitis; Miscellaneous; Clinical Features and General Management; Cardiovascular; Respiratory; Neurological; Metabolic, Gastroenterology and Nutrition
Immunity and BacteremiaAcute Kidney Injury; Coagulation; Prognosis of ALF; King's College Criteria; Clichy Criteria; MELD and Liver Volumes; Contraindications to Liver Transplantation; Summary; References; 4: The Splanchnic and Systemic Circulation in Liver Disease; Introduction; Physiology; Portal Pressure and Hypertension; The Role of Vasopressin in Liver Disease; Summary; References; 5: Drug Metabolism in Liver Failure; Introduction; Pharmacokinetics (PK) and Pharmacodynamics (PD); Effect of Liver Faiure on Medication PK and PD; Absorption; Protein Binding and Distribution; Metabolism