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Intro; Preface; Contents; Contributors; Abbreviations; Extracellular Matrix; 1 The Extracellular Matrix, Growth Factors and Morphogens in Biomaterial Design and Tissue Engineering; Abstract; Introduction; Key Molecular ECM Components; Prominent Role of the Proteoglycans and Glycosaminoglycans; Fibrous Proteins and Adhesive Glycoproteins; Growth Factors; Protease Activity and Role of Proteolytic Enzyme in ECM; Extracellular Vesicles in the ECM Structure/Organization; Importance of ECM-Integrin Interactions; Mechanical Signals Inside the ECM; Morphogenesis
Morphogenesis of 3D Tissue Architecture in Vivo: Folds, Tubes, and BranchesGrowth Factors and Morphogens for Tissue Engineering; Growth Factor and Morphogen Delivery Through Engineered ECM; Engineering Growth Factors and Morphogens for Interaction with Exogenous Biomaterials and for Delivery Through the Native ECM; References; 2 ECM Hydrogels for Regenerative Medicine; Abstract; Historical Development of ECM-Derived Materials; Biochemical Content; Bioinductive Properties; Antimicrobial Properties; Chemoattraction; Macrophage Polarization; Types of ECM-Derived Materials; ECM Hydrogel Formation
Methods for ECM Hydrogel ProductionECM Hydrogel Characterization; Biocompatibility; Biochemical Composition; Gelation Kinetics and Mechanical Properties; Gel Topology; Tissue-Specific Hydrogels; Heart; Fat; Skin; Liver; Skeletal Muscle; Central Nervous System; Cartilage; Tendon and Ligament; Intervertebral Disk; Others; Hybrid Hydrogels; Future Directions; References; 3 Biologically Relevant Laminins in Regenerative Medicine; Abstract; Introduction; Cell Niche and Extracellular Matrix; Expanding Cells in Vitro: Future of Regenerative Medicine
Three Pillars of Cell Niche: Growth Factors, Cell-Cell Contacts, and Niche-Specific Extracellular MatrixLaminins: Sixteen Niche-Specific Extracellular Matrix Molecules with Unique Biological Function; Laminins: Molecular Aspects and Cell Signaling; Laminins: Chains and Trimers; Molecular Interactions of Laminins; Interactions with Cell Receptors and Co-Signaling; Extracellular Matrix Interactions; Mechanotransduction; Proteolytically Degraded Forms of Laminins; Possible Antagonistic Functions of Related Laminins; Biologically Relevant Laminins for In Vitro Cell and Organoid Cultures
Human and Mouse Embryonic Stem CellsBone Marrow-Derived Hematopoietic Stem Cells; Insulin-Producing Pancreatic Islets; Neurobiology; Evaluation Criteria in Developing Cell Culture System; Future Challenges; Summary; Acknowledgements; References; 4 Extracellular Matrix: Immunity and Inflammation; Abstract; The Extracellular Matrix; Matrix Metalloproteinases (MMPs); Versican; Hyaluronan; Thrombospondins; Cells; Inflammation; Metalloproteinases and Inflammation; Versican and Inflammation; Hyaluronan and Inflammation; Thrombospondins and Inflammation; Immunity; Metalloproteinases and Immunity
Morphogenesis of 3D Tissue Architecture in Vivo: Folds, Tubes, and BranchesGrowth Factors and Morphogens for Tissue Engineering; Growth Factor and Morphogen Delivery Through Engineered ECM; Engineering Growth Factors and Morphogens for Interaction with Exogenous Biomaterials and for Delivery Through the Native ECM; References; 2 ECM Hydrogels for Regenerative Medicine; Abstract; Historical Development of ECM-Derived Materials; Biochemical Content; Bioinductive Properties; Antimicrobial Properties; Chemoattraction; Macrophage Polarization; Types of ECM-Derived Materials; ECM Hydrogel Formation
Methods for ECM Hydrogel ProductionECM Hydrogel Characterization; Biocompatibility; Biochemical Composition; Gelation Kinetics and Mechanical Properties; Gel Topology; Tissue-Specific Hydrogels; Heart; Fat; Skin; Liver; Skeletal Muscle; Central Nervous System; Cartilage; Tendon and Ligament; Intervertebral Disk; Others; Hybrid Hydrogels; Future Directions; References; 3 Biologically Relevant Laminins in Regenerative Medicine; Abstract; Introduction; Cell Niche and Extracellular Matrix; Expanding Cells in Vitro: Future of Regenerative Medicine
Three Pillars of Cell Niche: Growth Factors, Cell-Cell Contacts, and Niche-Specific Extracellular MatrixLaminins: Sixteen Niche-Specific Extracellular Matrix Molecules with Unique Biological Function; Laminins: Molecular Aspects and Cell Signaling; Laminins: Chains and Trimers; Molecular Interactions of Laminins; Interactions with Cell Receptors and Co-Signaling; Extracellular Matrix Interactions; Mechanotransduction; Proteolytically Degraded Forms of Laminins; Possible Antagonistic Functions of Related Laminins; Biologically Relevant Laminins for In Vitro Cell and Organoid Cultures
Human and Mouse Embryonic Stem CellsBone Marrow-Derived Hematopoietic Stem Cells; Insulin-Producing Pancreatic Islets; Neurobiology; Evaluation Criteria in Developing Cell Culture System; Future Challenges; Summary; Acknowledgements; References; 4 Extracellular Matrix: Immunity and Inflammation; Abstract; The Extracellular Matrix; Matrix Metalloproteinases (MMPs); Versican; Hyaluronan; Thrombospondins; Cells; Inflammation; Metalloproteinases and Inflammation; Versican and Inflammation; Hyaluronan and Inflammation; Thrombospondins and Inflammation; Immunity; Metalloproteinases and Immunity