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Anticoagulation therapy / Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff editors.

Lau, Joe F., editor.; Barnes, Geoffrey D., editor.; Streiff, Michael B., editor.
2018
RM340
Available Online
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Title
Anticoagulation therapy / Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff editors.
ISBN
9783319737096 (electronic book)
3319737090 (electronic book)
9783319737089
3319737082
DOI
https://doi.org/10.1007/978-3-319-73709-6
Published
Cham, Switzerland : Springer, [2018]
Copyright
©2018
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-319-73709-6 doi
Call Number
RM340
Dewey Decimal Classification
615.718
Summary
This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.
Bibliography, etc. Note
Includes bibliographical references and index.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Vendor-supplied metadata.
Added Author
Lau, Joe F., editor.
Barnes, Geoffrey D., editor.
Streiff, Michael B., editor.
Available in Other Form
Print version: 9783319737089
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Online Access
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Intro; Preface; Acknowledgments; Abbreviations; Contents; 1: Introduction; Anticoagulation Therapy: A Historical Perspective; The Evolving Anticoagulant Armamentarium; Resources for Anticoagulation Management; Exploring the Future of Anticoagulation Care; References; Part I: Anticoagulants; 2: Warfarin; Introduction; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Practical Management; Patient Engagement and Education; Dosing: Initiation; Dosing: Maintenance; Administration; Monitoring

Transitioning Between Warfarin and Other AnticoagulantsManagement of Warfarin Around Elective Procedures; Adverse Effects; Skin Necrosis; Purple Toe Syndrome; Other Adverse Effects; Bleeding; Reversal; INR Derangements in Asymptomatic Patients; INR 9; Bleeding Events; Nonmajor Bleeding; Major Bleeding; Urgent or Emergent Procedures; Special Considerations; Pregnancy; Breastfeeding; Pediatric Patients; Conclusion; References; 3: Unfractionated Heparin and Low-­Molecular-­Weight Heparin; Introduction; Unfractionated Heparin; Pharmacokinetics and Pharmacodynamics

Clinical Indications and DosingMonitoring; Considerations in Special Populations; Obesity; Pregnancy; Strategies for Reversal of Unfractionated Heparin; Complications; Heparin Resistance; Osteopenia; Heparin-Induced Thrombocytopenia; Low-Molecular-Weight Heparin; Pharmacodynamics; Pharmacokinetics; Clinical Indications and Dosing; Considerations in Special Populations; Obesity; Renal Dysfunction and Elderly Patients; Pregnancy; Strategies for Reversal of Low-­Molecular-­Weight Heparins; Summary; References; 4: Parenteral Anticoagulants: Direct Thrombin Inhibitors and Pentasaccharides

Parenteral Direct Thrombin Inhibitors (Argatroban and Bivalirudin)Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Heparin-Induced Thrombocytopenia (HIT); Argatroban; Bivalirudin; Coronary Reperfusion; Percutaneous Coronary Intervention (PCI) in Patients without HIT; Argatroban; Bivalirudin; Percutaneous Coronary Intervention (PCI) in Patients with HIT; Argatroban; Bivalirudin; Acute Myocardial Infarction (NSTEMI or STEMI) in Patients Who Cannot Undergo PCI; CABG with or Without HIT

Practical ManagementDosing; Administration; Monitoring and Titration; HIT; Coronary Reperfusion; Argatroban; Bivalirudin; Transitioning to Oral Anticoagulation; HIT; Argatroban; Bivalirudin; Coronary Reperfusion; Other Clinical Uses; Continuous Renal Replacement Therapy; ECMO; Adverse Effects; Reversal; Special Considerations; Pregnancy; Breastfeeding; Pediatric; Fondaparinux; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Renal Function; Age; Low Body Weight; Pharmacodynamics; Clinical Utility; Prevention of VTE; Orthopedic Surgery

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