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Table of Contents
Intro; Preface; Contents; Contributors; 1: History of Acute Promyelocytic Leukemia; Introduction; A Distinct Entity: "A Special Type of Leukemia" (1957-1987); The Clinical Description; A Controversy About Treatment; A Cytogenetic Signature; A New Paradigm: The Differentiation of Malignant Cells; Abolishing the Dogma of the Irreversible Status of Malignant Cells; An Experimental Approach; A Clinical Approach; All-Trans-Retinoic Acid as a Potential Candidate for Differentiation Therapy of APL; The Dinner that Initiated All-Trans-Retinoic Acid Treatment for APL (1985); Hoops and Hurdles
No More ProductIs APL a Pseudo-Leukemia?; Early Relapses with ATRA; Hope for a Curable Disease; Worldwide Enthusiasm; New Clinical Horizons, Unknown Conditions; Nonstandard Regimens; Molecular Defects; First Attempts at Molecular Approaches; Clinical Consequences: Diagnostic and Follow-Up Tools; Toward a Biological Explanation of Oncogenesis and Restoration; Arsenic, a Manchurian Traditional Medicine (1995); A Second Era for Clinicians; A Better Biological Understanding; ATRA-ATO Combination in Patients: From Curable to Cured APL; And Beyond: Lessons and Questions; References
2: Molecular Targets of Treatment in Acute Promyelocytic LeukemiaIntroduction; The Translocation Partners: RARA and PML; The Oncoprotein PML/RARA; Therapeutic Effects of Retinoic Acid in APL; Uncoupling Differentiation and Loss of Clonogenicity Under RA Treatment; RA-Induced PML/RARA Degradation; Role of PML and p53 in the Cure of APL Under RA Treatment; Therapeutic Effects of Arsenic Trioxide in APL; ATO-Induced PML NB Reformation and PML/RARA Degradation; RA and ATO Synergy in APL Cure; References; 3: The Leukemic Stem Cell; The Cancer Stem Cell Theory; Defining Stemness in Leukemia
The Effects of ATRA and ATO on the Coagulopathy of APLManagement of the Coagulopathy; Platelet Transfusions, Heparin, and Antifibrinolytic Agents; References; 6: Early Death in Acute Promyelocytic Leukemia; Introduction; Definition and Timing of Early Death; Early Death in the Pre-ATRA Era; Early Death in Clinical Trials vs. Population-Based Studies; Causes of Early Death; Bleeding; Infections; Thrombosis; Differentiation Syndrome (DS); Organ Failure; Early Death Risk Factors; Role of ATRA in Early Death; Early Death over Time; Prevention of ED; References
No More ProductIs APL a Pseudo-Leukemia?; Early Relapses with ATRA; Hope for a Curable Disease; Worldwide Enthusiasm; New Clinical Horizons, Unknown Conditions; Nonstandard Regimens; Molecular Defects; First Attempts at Molecular Approaches; Clinical Consequences: Diagnostic and Follow-Up Tools; Toward a Biological Explanation of Oncogenesis and Restoration; Arsenic, a Manchurian Traditional Medicine (1995); A Second Era for Clinicians; A Better Biological Understanding; ATRA-ATO Combination in Patients: From Curable to Cured APL; And Beyond: Lessons and Questions; References
2: Molecular Targets of Treatment in Acute Promyelocytic LeukemiaIntroduction; The Translocation Partners: RARA and PML; The Oncoprotein PML/RARA; Therapeutic Effects of Retinoic Acid in APL; Uncoupling Differentiation and Loss of Clonogenicity Under RA Treatment; RA-Induced PML/RARA Degradation; Role of PML and p53 in the Cure of APL Under RA Treatment; Therapeutic Effects of Arsenic Trioxide in APL; ATO-Induced PML NB Reformation and PML/RARA Degradation; RA and ATO Synergy in APL Cure; References; 3: The Leukemic Stem Cell; The Cancer Stem Cell Theory; Defining Stemness in Leukemia
The Effects of ATRA and ATO on the Coagulopathy of APLManagement of the Coagulopathy; Platelet Transfusions, Heparin, and Antifibrinolytic Agents; References; 6: Early Death in Acute Promyelocytic Leukemia; Introduction; Definition and Timing of Early Death; Early Death in the Pre-ATRA Era; Early Death in Clinical Trials vs. Population-Based Studies; Causes of Early Death; Bleeding; Infections; Thrombosis; Differentiation Syndrome (DS); Organ Failure; Early Death Risk Factors; Role of ATRA in Early Death; Early Death over Time; Prevention of ED; References