@article{838816,
      recid = {838816},
      author = {Bassaganya-Riera, Josep,},
      title = {Accelerated path to cures /},
      pages = {1 online resource :},
      abstract = {Accelerated Path to Cures provides a transformative  perspective on the power of combining advanced  computational technologies, modeling, bioinformatics and  machine learning approaches with nonclinical and clinical  experimentation to accelerate drug development. This book  discusses the application of advanced modeling  technologies, from target identification and validation to  nonclinical studies in animals to Phase 1-3 human clinical  trials and post-approval monitoring, as alternative models  of drug development. As a case of successful integration of  computational modeling and drug development, we discuss the  development of oral small molecule therapeutics for  inflammatory bowel disease, from the application of docking  studies to screening new chemical entities to the  development of next-generation in silico human clinical  trials from large-scale clinical data. Additionally, this  book illustrates how modeling techniques, machine learning,  and informatics can be utilized effectively at each stage  of drug development to advance the progress towards  predictive, preventive, personalized, precision medicine,  and thus provide a successful framework for Path to Cures.  .},
      url = {http://library.usi.edu/record/838816},
      doi = {https://doi.org/10.1007/978-3-319-73238-1},
}