Total synthesis of natural products with antimicrobial activity / Andrew Giltrap.
Giltrap, Andrew, author.
2018
QD375
Available Online

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Title Total synthesis of natural products with antimicrobial activity / Andrew Giltrap.
Author Giltrap, Andrew, author.
ISBN 9789811088063 (electronic book)
9811088063 (electronic book)
9789811088056
9811088055
DOI https://doi.org/10.1007/978-981-10-8806-3
Published Singapore : Springer, 2018.
Language English
Description 1 online resource (xxiv, 268 pages) : illustrations.
Other Standard Identifiers 10.1007/978-981-10-8806-3 doi
Call Number QD375
Dewey Decimal Classification 615.7/92
Summary This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Series Springer theses.
Available in Other Form Print version: 9789811088056
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Introduction
Total Synthesis of Teixobactin
Synthesis of Deshydroxy Skyllamycins A-C
Total Synthesis of Skyllamycins A-C
Experimental.

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