@article{838891,
      author = {Giltrap, Andrew,},
      url = {http://library.usi.edu/record/838891},
      title = {Total synthesis of natural products with antimicrobial  activity /},
      abstract = {This thesis focuses on the development of efficient and  scalable total syntheses of natural products that can be  used as preferred scaffolds for anti-infective drug  discovery. It describes the total synthesis of two classes  of antimicrobial non-ribosomal peptides (NRPs) -  teixobactin and the skyllamycins - with subsequent  biological evaluation. The first part describes the first  total synthesis of teixobactin by means of a solid-phase  peptide synthesis-macrolactamisation approach, yielding a  synthetic natural product that can combat a number of  clinically relevant Gram-positive bacterial pathogens. The  second part describes the first total synthesis of  skyllamycins A-C, a family of structurally complex cyclic  NRPs, which inhibit the growth of the Pseudomonas  aeruginosa biofilms that are responsible for significant  mortality among cystic fibrosis patients.},
      doi = {https://doi.org/10.1007/978-981-10-8806-3},
      recid = {838891},
      pages = {1 online resource (xxiv, 268 pages) :},
}