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000838891 019__ $$a1035301048
000838891 020__ $$a9789811088063$$q(electronic book)
000838891 020__ $$a9811088063$$q(electronic book)
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000838891 0247_ $$a10.1007/978-981-10-8806-3$$2doi
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000838891 035__ $$aSP(OCoLC)1034540516$$z(OCoLC)1035301048
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000838891 049__ $$aISEA
000838891 050_4 $$aQD375
000838891 08204 $$a615.7/92$$223
000838891 1001_ $$aGiltrap, Andrew,$$eauthor.
000838891 24510 $$aTotal synthesis of natural products with antimicrobial activity /$$cAndrew Giltrap.
000838891 264_1 $$aSingapore :$$bSpringer,$$c2018.
000838891 300__ $$a1 online resource (xxiv, 268 pages) :$$billustrations.
000838891 336__ $$atext$$btxt$$2rdacontent
000838891 337__ $$acomputer$$bc$$2rdamedia
000838891 338__ $$aonline resource$$bcr$$2rdacarrier
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000838891 4901_ $$aSpringer theses,$$x2190-5053
000838891 5050_ $$aIntroduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.
000838891 506__ $$aAccess limited to authorized users.
000838891 520__ $$aThis thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
000838891 650_0 $$aNatural products.
000838891 650_0 $$aAnti-infective agents.
000838891 650_0 $$aPharmaceutical chemistry.
000838891 650_0 $$aClinical biochemistry.
000838891 77608 $$iPrint version:$$z9789811088056
000838891 830_0 $$aSpringer theses.
000838891 852__ $$bebk
000838891 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-10-8806-3$$zOnline Access$$91397441.1
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000838891 980__ $$aEBOOK
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000838891 983__ $$aOnline
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