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000839143 019__ $$a1034987648$$a1035284995$$a1040613301
000839143 020__ $$a9783319742595$$q(electronic book)
000839143 020__ $$a3319742590$$q(electronic book)
000839143 020__ $$z9783319742588
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000839143 0247_ $$a10.1007/978-3-319-74259-5$$2doi
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000839143 050_4 $$aRC268.4
000839143 08204 $$a616.99/4042$$223
000839143 24500 $$aHereditary colorectal cancer :$$bgenetic basis and clinical implications /$$cLaura Valle, Stephen B. Gruber, Gabriel Capellá, editors.
000839143 264_1 $$aCham :$$bSpringer,$$c[2018]
000839143 264_4 $$c©2018
000839143 300__ $$a1 online resource :$$billustrations.
000839143 336__ $$atext$$btxt$$2rdacontent
000839143 337__ $$acomputer$$bc$$2rdamedia
000839143 338__ $$aonline resource$$bcr$$2rdacarrier
000839143 347__ $$atext file$$bPDF$$2rda
000839143 504__ $$aIncludes bibliographical references and index.
000839143 5050_ $$aPart1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome -- The molecular basis of Lynch-like syndrome -- Constitutional mismatch repair deficiency -- Mismatch repair proficient hereditary non-polyposis colorectal cancer -- Genetic and environmental modifiers of risk in Lynch syndrome -- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction -- Familial adenomatous polyposis -- Polymerase proofreading-associated polyposis -- MUTYH-associated polyposis -- NTHL1-associated polyposis -- Germline biallelic inactivation of MMR genes (with polyposis phenotype) -- Unexplained adenomatous polyposis -- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome -- Juvenile polyposis syndrome -- PTEN-hamartoma tumor syndromes -- Other hamartomatous polyposis conditions -- HEREDITARY MIXED POLYPOSIS SYNDROME -- SERRATED POLYPOSIS SYNDROME -- Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT -- Genetic testing in hereditary colorectal cancer -- Universal tumor screening for Lynch syndrome -- Classification of genetic variants. Prediction models for Lynch syndrome -- Surveillance guidelines for hereditary colorectal cancer syndromes -- Surgical management of hereditary colorectal cancer syndromes -- Chemoprevention in hereditary colorectal cancer syndromes -- Immunotherapy in hereditary colorectal cancer -- The Immune Biology of Microsatellite Unstable cancer -- Hereditary colorectal cancer: Immunotherapy approaches -- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES -- Databases: intentions, capabilities and limitations -- The Colon Cancer Family Registry Cohort -- The Prospective Lynch Syndrome Database -- The InSiGHT Database: An example LOVD system -- The International Mismatch Repair Consortium.
000839143 506__ $$aAccess limited to authorized users.
000839143 520__ $$aThis book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
000839143 588__ $$aOnline resource ; title from PDF title page (viewed  May 9, 2018).
000839143 650_0 $$aColon (Anatomy)$$xCancer$$xGenetic aspects.
000839143 650_0 $$aRectum$$xCancer$$xGenetic aspects.
000839143 650_0 $$aCancer genes.
000839143 7001_ $$aValle, Laura,$$eeditor.
000839143 7001_ $$aGruber, Stephen B.,$$eeditor.
000839143 7001_ $$aCapellá, Gabriel,$$eeditor.
000839143 77608 $$iPrint version: $$z3319742582$$z9783319742588$$w(OCoLC)1016050053
000839143 852__ $$bebk
000839143 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-74259-5$$zOnline Access$$91397441.1
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000839143 980__ $$aEBOOK
000839143 980__ $$aBIB
000839143 982__ $$aEbook
000839143 983__ $$aOnline
000839143 994__ $$a92$$bISE